Synthesis of heterocycles through hydrosilylation, silylformylation, silylcarbocyclization and cyclohydrocarbonylation reactions

Greta Varchi, Iwao Ojima

Research output: Contribution to journalReview article

40 Scopus citations

Abstract

The design and development of highly efficient catalytic methods for the synthesis of carbocycles and heterocycles has been the subject of extensive study, because of their relevance to life sciences and material sciences. Among various available synthetic methods, the transition-metal-catalyzed cyclization reactions has attracted much attention for the transformation of simple starting materials into heterocyclic scaffolds, which can be further elaborated into more specific targets. Accordingly, this review describes recent advances in the synthesis of heterocycles by means of intramolecular hydrosilylation, intramolecular silylformylation, silylcarbocyclization (SiCaC), and cyclohydrocarbonylation reactions.

Original languageEnglish (US)
Pages (from-to)1341-1362
Number of pages22
JournalCurrent Organic Chemistry
Volume10
Issue number12
DOIs
StatePublished - Aug 1 2006

Keywords

  • Cycloisomerization
  • Dimethylsiloxyalkadiynes
  • Enediynes
  • Homopropargylic alcohols
  • Ru catalyst hydrosilylation
  • Tandem addtion

ASJC Scopus subject areas

  • Organic Chemistry

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