Synthesis of deserpidine from reserpine

Greta Varchi, Arturo Battaglia, Cristian Samorì, Eleonora Baldelli, Bruno Danieli, Gabriele Fontana, Andrea Guerrini, Ezio Bombardelli

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


The Rauwolfia alkaloids reserpine (1) and deserpidine (2), two alkaloids from Rauwolfia species, have been widely used for their antihypertensive action. Deserpidine (2) is a compound with limited availability from natural sources, and its synthesis from 1 in six steps (41% overall yield) is reported here.

Original languageEnglish (US)
Pages (from-to)1629-1631
Number of pages3
JournalJournal of Natural Products
Issue number11
StatePublished - Nov 1 2005

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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