Synthesis of deserpidine from reserpine

Greta Varchi, Arturo Battaglia, Cristian Samorì, Eleonora Baldelli, Bruno Danieli, Gabriele Fontana, Andrea Guerrini, Ezio Bombardelli

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The Rauwolfia alkaloids reserpine (1) and deserpidine (2), two alkaloids from Rauwolfia species, have been widely used for their antihypertensive action. Deserpidine (2) is a compound with limited availability from natural sources, and its synthesis from 1 in six steps (41% overall yield) is reported here.

Original languageEnglish (US)
Pages (from-to)1629-1631
Number of pages3
JournalJournal of Natural Products
Volume68
Issue number11
DOIs
StatePublished - Nov 1 2005

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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