Synthesis of deserpidine from reserpine

Greta Varchi; Arturo Battaglia; Cristian Samorì; Eleonora Baldelli; Bruno Danieli; Gabriele Fontana; Andrea Guerrini; Ezio Bombardelli

doi:10.1021/np050179x

Synthesis of deserpidine from reserpine

Greta Varchi, Arturo Battaglia, Cristian Samorì, Eleonora Baldelli, Bruno Danieli, Gabriele Fontana, Andrea Guerrini, Ezio Bombardelli

Houston Methodist

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

The Rauwolfia alkaloids reserpine (1) and deserpidine (2), two alkaloids from Rauwolfia species, have been widely used for their antihypertensive action. Deserpidine (2) is a compound with limited availability from natural sources, and its synthesis from 1 in six steps (41% overall yield) is reported here.

Original language	English (US)
Pages (from-to)	1629-1631
Number of pages	3
Journal	Journal of Natural Products
Volume	68
Issue number	11
DOIs	https://doi.org/10.1021/np050179x
State	Published - Nov 1 2005

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np050179x

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abstract = "The Rauwolfia alkaloids reserpine (1) and deserpidine (2), two alkaloids from Rauwolfia species, have been widely used for their antihypertensive action. Deserpidine (2) is a compound with limited availability from natural sources, and its synthesis from 1 in six steps (41% overall yield) is reported here.",

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AU - Varchi, Greta

AU - Battaglia, Arturo

AU - Samorì, Cristian

AU - Baldelli, Eleonora

AU - Danieli, Bruno

AU - Fontana, Gabriele

AU - Guerrini, Andrea

AU - Bombardelli, Ezio

PY - 2005/11/1

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N2 - The Rauwolfia alkaloids reserpine (1) and deserpidine (2), two alkaloids from Rauwolfia species, have been widely used for their antihypertensive action. Deserpidine (2) is a compound with limited availability from natural sources, and its synthesis from 1 in six steps (41% overall yield) is reported here.

AB - The Rauwolfia alkaloids reserpine (1) and deserpidine (2), two alkaloids from Rauwolfia species, have been widely used for their antihypertensive action. Deserpidine (2) is a compound with limited availability from natural sources, and its synthesis from 1 in six steps (41% overall yield) is reported here.

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Synthesis of deserpidine from reserpine

Abstract

ASJC Scopus subject areas

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