Synthesis of Collagenase-Sensitive Polyureas for Ligament Tissue Engineering

Hugh Benhardt, Nicholas Sears, Tyler Touchet, Elizabeth Cosgriff-Hernandez

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Recently, poly(ester urethanes) were investigated for use as ligament grafts due to their exceptional mechanical properties and highly tunable structure; however, these grafts are susceptible to hydrolytic degradation that occurs independent of tissue regeneration. To address this limitation, polyureas containing collagen-derived peptides were synthesized which enable cellular release of proteases to dictate degradation rate. It is hypothesized that this cell-responsive design will facilitate load transfer from the biodegradable scaffold to neotissue at a rate that promotes proper tissue orientation and function while maintaining construct integrity. Ligament scaffolds with cell-responsive biodegradation. Polyether prepolymers are functionalized with reactive end groups to enable incorporation of an enzyme labile peptide into the polyurea backbone. The addition of cell-responsive degradation to one of the most versatile classes of biomaterials makes these hybrid grafts promising candidates for tissue engineered ligament grafts.

Original languageEnglish (US)
Pages (from-to)1020-1030
Number of pages11
JournalMacromolecular Bioscience
Volume11
Issue number8
DOIs
StatePublished - Aug 11 2011

Keywords

  • Biomimetic
  • Ligament
  • Polyurea
  • Synthesis
  • Tissue engineering

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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