Synthesis of a novel methylene-bridged biscarbazole derivative and evaluation of its DNA and nucleotide binding properties

Gang Li, Xue Zhou, Peng Yang, Yong Jian, Tuo Deng, Hongyan Shen, Ying Bao

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The synthesis of a novel methylene-bridged biscarbazole derivative 1 was described and the possible mechanism for its unexpectedly synthesized intermediate, compound A, was postulated. The binding properties of 1 to both Ct-DNA and nucleotides were investigated via fluorescent and UV-Vis spectra. The spectral investigations illustrated that this binary carbazole exhibited higher binding abilities to both Ct-DNA and nucleotides than its monomeric form, owing to the structurally flexible nature of double carbazole moieties fine-tuned by this non rigid methylene-linkage.

Original languageEnglish (US)
Pages (from-to)7054-7059
Number of pages6
JournalTetrahedron Letters
Volume55
Issue number51
DOIs
StatePublished - Dec 17 2014
Externally publishedYes

Keywords

  • Biscarbazole
  • DNA binding
  • Fluorescence
  • Nucleotide binding
  • UV-Vis spectra

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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