Synthesis, characterization and antimicrobial activity of macrocylic phenoxo-bridged di- and tetra-nuclear complexes from N,N-bis[2,6-diiminomethyl- 4-methyl-1-hydroxyphenyl]succinoyl/sebacoyldicarboxamides

B. H.M. Mruthyunjayaswamy, Y. Jadegoud, Omkar B. Ijare, Somanath G. Patil, Shreeshaila M. Kudari

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Macrocyclic ligands NN-bis[26-diiminomethyl-4-methyl-1-hydroxyphenyl] succinoyl dicarboxamide (H2L1) and NN-bis[26- diiminomethyl-4-methyl-1-hydroxyphenyl]sebacoyl dicarboxamide (H 2L2) were synthesized and characterized by various spectral techniques. Macrocyclic di- and tetra-homonuclear phenoxo bridged CuII CoII NiII ZnII CdII and HgII complexes have been synthesized through the template method by using the precursors 26-diformyl-4-methylphenol succinoyldihydrazide/ sebacoyldihydrazide and respective metal chlorides in 2:2:2/2:2:4 ratio respectively. The synthesized complexes were characterized by i.r. n.m.r. u.v.-vis. FAB-mass e.s.r. magnetic susceptibility and elemental analyses data. The elemental analyses and FAB-mass spectral data have justified the dinuclear and tetra nuclear structure for the complexes of the ligands H2L 1 and H2L2 respectively. The observed low magnetic moment values revealed the existence of antiferromagnetic spin exchange interaction operating between the two metal centers. Electronic data suggested the octahedral geometry for NiII complexes and square pyramidal geometry for CuII CoII ZnII CdII and HgII complexes of both the ligands. The CuII Co II and ZnII complexes of both the ligands have shown good antifungal activity against Aspergillus niger and Fusarium oxysporum and medium to weak antibacterial activity against Escherichia coli and Staphylococcus aureus when compared to the standard drugs Grisefulvin and Ciprofloxacin respectively.

Original languageEnglish (US)
Pages (from-to)234-242
Number of pages9
JournalTransition Metal Chemistry
Volume30
Issue number2
DOIs
StatePublished - Mar 1 2005

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Metals and Alloys
  • Materials Chemistry

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