Synthesis and Imaging of Biocompatible Graphdiyne Quantum Dots

Huan Min, Yingqiu Qi, Yanhuan Chen, Yinlong Zhang, Xuexiang Han, Ying Xu, Ying Liu, Jianshe Hu, Hiubiao Liu, Yiye Li, Guangjun Nie

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Graphdiyne has attracted much interest from researchers for their potential applications in energy storage, catalysis, and biomedical areas. As one of the derivatives of graphdiyne, graphdiyne quantum dots (GDQDs) may possess superior bioactivity due to active acetylene units. However, the biological application of biocompatible GDQDs have not been reported so far. Herein, GDQDs with uniform size and good crystallization were prepared via a classical solvothermal method. The GDQDs exhibit excitation- and pH-dependent fluorescence emission as well as superior photostability, demonstrating their potential for bioimaging. The GDQDs demonstrate efficient cellular uptake and cell imaging without induction of detectable cytotoxic effects in vitro. Systematical safety evaluation further confirmed good biocompatibility of the GDQDs in vivo. Our study preliminarily validates the application of the GDQDs in biomedicine and encourages more thorough studies for better realizing the potential of GDQDs.

Original languageEnglish (US)
Pages (from-to)32798-32807
Number of pages10
JournalACS Applied Materials and Interfaces
Issue number36
StatePublished - Sep 11 2019


  • biocompatibility
  • bioimaging
  • graphdiyne
  • nanomaterial
  • quantum dots

ASJC Scopus subject areas

  • Materials Science(all)


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