TY - JOUR
T1 - Synthesis and characterization of hydroxylated polychlorinated biphenyls (PCBs) identified in human serum
AU - Safe, Stephen
AU - Washburn, Kent
AU - Zacharewski, Timothy
AU - Phillips, Timothy
N1 - Funding Information:
The financial assistance of the National Institutes of Health (P42-ES04917) and the Texas Agricultural Experiment Station is gratefully acknowledged. Dr. T. Zacharewski is supported by PMAC-HRF-MRC research award in medicine.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1995/8
Y1 - 1995/8
N2 - Hydroxylated polychlorinated biphenyls (PCBs) have been identified in wildlife and human samples. Most of these compounds are highly chlorinated (penta-hepatachloro) and contain a single meta- or para-hydroxyl group. Using the Cadogan coupling procedure, the following hydroxy-PCBs congeners were synthesized: 2,3,3′,4′,5- pentachloro-4-biphenylol, 2,3′,4,4′,5-pentachloro-3-biphenylol, 2′,3,3′,4′,5-pentachloro-4-biphenylol, 2,2′,3′,4,4′-pentachloro-3-biphenylol, 2,2′,3,3′,4′,5-pentachloro-4-biphenylol, 2,2′,3′,4,4′,5-hexachloro-3-biphenylol, 2,2′,3,4′,5,5′-hexachloro-4-biphenylol, 2,2′,3,3′,4′,5,5′-heptachloro-4-biphenylol, 2,2′,3′,4,4′,5,5′-heptachloro-3-biphenylol, 2,2′,3,4′,5,5′,6-heptachloro-4-biphenylol. Many of these compounds have been detected as residues in human serum and current studies are investigating their activities as agonists and antagonists for several endocrine-mediated responses.
AB - Hydroxylated polychlorinated biphenyls (PCBs) have been identified in wildlife and human samples. Most of these compounds are highly chlorinated (penta-hepatachloro) and contain a single meta- or para-hydroxyl group. Using the Cadogan coupling procedure, the following hydroxy-PCBs congeners were synthesized: 2,3,3′,4′,5- pentachloro-4-biphenylol, 2,3′,4,4′,5-pentachloro-3-biphenylol, 2′,3,3′,4′,5-pentachloro-4-biphenylol, 2,2′,3′,4,4′-pentachloro-3-biphenylol, 2,2′,3,3′,4′,5-pentachloro-4-biphenylol, 2,2′,3′,4,4′,5-hexachloro-3-biphenylol, 2,2′,3,4′,5,5′-hexachloro-4-biphenylol, 2,2′,3,3′,4′,5,5′-heptachloro-4-biphenylol, 2,2′,3′,4,4′,5,5′-heptachloro-3-biphenylol, 2,2′,3,4′,5,5′,6-heptachloro-4-biphenylol. Many of these compounds have been detected as residues in human serum and current studies are investigating their activities as agonists and antagonists for several endocrine-mediated responses.
KW - characterization
KW - hydroxy-PCBs
KW - synthesis
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U2 - 10.1016/0045-6535(95)00162-2
DO - 10.1016/0045-6535(95)00162-2
M3 - Article
C2 - 7552046
AN - SCOPUS:0029097209
VL - 31
SP - 3017
EP - 3023
JO - Chemosphere
JF - Chemosphere
SN - 0045-6535
IS - 4
ER -