Synthesis and characterization of hydroxylated polychlorinated biphenyls (PCBs) identified in human serum

Stephen Safe, Kent Washburn, Timothy Zacharewski, Timothy Phillips

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Hydroxylated polychlorinated biphenyls (PCBs) have been identified in wildlife and human samples. Most of these compounds are highly chlorinated (penta-hepatachloro) and contain a single meta- or para-hydroxyl group. Using the Cadogan coupling procedure, the following hydroxy-PCBs congeners were synthesized: 2,3,3′,4′,5- pentachloro-4-biphenylol, 2,3′,4,4′,5-pentachloro-3-biphenylol, 2′,3,3′,4′,5-pentachloro-4-biphenylol, 2,2′,3′,4,4′-pentachloro-3-biphenylol, 2,2′,3,3′,4′,5-pentachloro-4-biphenylol, 2,2′,3′,4,4′,5-hexachloro-3-biphenylol, 2,2′,3,4′,5,5′-hexachloro-4-biphenylol, 2,2′,3,3′,4′,5,5′-heptachloro-4-biphenylol, 2,2′,3′,4,4′,5,5′-heptachloro-3-biphenylol, 2,2′,3,4′,5,5′,6-heptachloro-4-biphenylol. Many of these compounds have been detected as residues in human serum and current studies are investigating their activities as agonists and antagonists for several endocrine-mediated responses.

Original languageEnglish (US)
Pages (from-to)3017-3023
Number of pages7
Issue number4
StatePublished - Aug 1995


  • characterization
  • hydroxy-PCBs
  • synthesis

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis


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