TY - JOUR
T1 - Synthesis and characterization of amine-functionalized amphiphilic block copolymers based on poly(ethylene glycol) and poly(caprolactone)
AU - Remant Bahadur, K. C.
AU - Bhattarai, Shanta Raj
AU - Aryal, Santosh
AU - Bhattarai, Narayan
AU - Lee, Byoung Min
AU - Kim, Hak Yong
PY - 2007/4
Y1 - 2007/4
N2 - A series of amine-functionalized block copolymers, poly(caprolactone)-block-poly(ethylene glycol) (PCL-b-PEG), were synthesized by ring-opening bulk polymerization (ROP) of ε-caprolactone (ε-CL) initiated through the hydroxyl end of the amino poly(ethylene glycol) (PEG) used as a macroinitiator in the presence of stannous 2-ethylhexonoate [Sn(Oct)2]. The polymerization and end functionality of the polymer were studied by different physicochemical techniques (1H NMR, Fourier transform infrared and X-ray photoelectron spectroscopy, gel permeation chromatography and thermogravimetric analysis). Thermal, crystalline and mechanical properties of the polymer were thoroughly analyzed using differential scanning calorimetry, wide-angle X-ray diffractometry and tensile testing, respectively. The results showed a linear improvement in crystallinity and mechanical properties of the polymer with the content of PEG. Thus the synthesized functional polymers can be used as excellent biomaterials for the delivery of polyanions, as well as macroinitiators for the synthesis of A-B-C-type block copolymers.
AB - A series of amine-functionalized block copolymers, poly(caprolactone)-block-poly(ethylene glycol) (PCL-b-PEG), were synthesized by ring-opening bulk polymerization (ROP) of ε-caprolactone (ε-CL) initiated through the hydroxyl end of the amino poly(ethylene glycol) (PEG) used as a macroinitiator in the presence of stannous 2-ethylhexonoate [Sn(Oct)2]. The polymerization and end functionality of the polymer were studied by different physicochemical techniques (1H NMR, Fourier transform infrared and X-ray photoelectron spectroscopy, gel permeation chromatography and thermogravimetric analysis). Thermal, crystalline and mechanical properties of the polymer were thoroughly analyzed using differential scanning calorimetry, wide-angle X-ray diffractometry and tensile testing, respectively. The results showed a linear improvement in crystallinity and mechanical properties of the polymer with the content of PEG. Thus the synthesized functional polymers can be used as excellent biomaterials for the delivery of polyanions, as well as macroinitiators for the synthesis of A-B-C-type block copolymers.
KW - Amphiphilic block copolymer
KW - Biomaterials
KW - Functional polymer
KW - Nanoparticles
KW - Ring-opening polymerization
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U2 - 10.1002/pi.2160
DO - 10.1002/pi.2160
M3 - Article
AN - SCOPUS:33947657400
SN - 0959-8103
VL - 56
SP - 518
EP - 524
JO - Polymer International
JF - Polymer International
IS - 4
ER -