Synthesis and characterization of amine-functionalized amphiphilic block copolymers based on poly(ethylene glycol) and poly(caprolactone)

K. C. Remant Bahadur, Shanta Raj Bhattarai, Santosh Aryal, Narayan Bhattarai, Byoung Min Lee, Hak Yong Kim

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

A series of amine-functionalized block copolymers, poly(caprolactone)-block-poly(ethylene glycol) (PCL-b-PEG), were synthesized by ring-opening bulk polymerization (ROP) of ε-caprolactone (ε-CL) initiated through the hydroxyl end of the amino poly(ethylene glycol) (PEG) used as a macroinitiator in the presence of stannous 2-ethylhexonoate [Sn(Oct)2]. The polymerization and end functionality of the polymer were studied by different physicochemical techniques (1H NMR, Fourier transform infrared and X-ray photoelectron spectroscopy, gel permeation chromatography and thermogravimetric analysis). Thermal, crystalline and mechanical properties of the polymer were thoroughly analyzed using differential scanning calorimetry, wide-angle X-ray diffractometry and tensile testing, respectively. The results showed a linear improvement in crystallinity and mechanical properties of the polymer with the content of PEG. Thus the synthesized functional polymers can be used as excellent biomaterials for the delivery of polyanions, as well as macroinitiators for the synthesis of A-B-C-type block copolymers.

Original languageEnglish (US)
Pages (from-to)518-524
Number of pages7
JournalPolymer International
Volume56
Issue number4
DOIs
StatePublished - Apr 1 2007

Keywords

  • Amphiphilic block copolymer
  • Biomaterials
  • Functional polymer
  • Nanoparticles
  • Ring-opening polymerization

ASJC Scopus subject areas

  • Polymers and Plastics

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