Synthesis and antibacterial activities of 4-amino-3-(1-aryl-5-methyl-1,2,3- triazol-4-yl)-5-mercapto-1,2,4-triazoles/2-amino-5-(1-aryl-5-methyl-1,2, 3-triazol-4-yl)-1,3,4-thiadiazoles and their derivatives

Yan Zhang, Xiao Wen Sun, Xin Ping Hui, Zi Yi Zhang, Qin Wang, Qi Zhang

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Treatment of 4-amino-3-(1-aryl-5-methyl-1,2,3-triazol-4-yl)-5-mercapto-1,2, 4-triazoles/2-amino-5-(1-aryl-5-methyl-1,2, 3-triazol-4-yl)-1,3,4-thiadiazoles with benzaldehyde, acetone and ω-bromoacetophenone was tested and compared. The title compounds Schiff bases, amides, imidazolo[2,1-b]-1,3,4- thiadiazoles and 7H-s-triazolo [3,4-b]-1,3,4-thiadiazines have been confirmed by elemental analyses, 1H NMR, IR and MS spectra. All the compounds have also been screened for their antibacterial activities against B. subtilis, S. aureus and E. coli.

Original languageEnglish (US)
Pages (from-to)168-173
Number of pages6
JournalChinese Journal of Chemistry
Volume20
Issue number2
DOIs
StatePublished - Feb 2002

Keywords

  • 7H-s-triazolo[3,4-b]- 1,3,4-thiadiazine
  • Amide
  • Imidazolo[2,1-b]-1,3,4-thiadiazole
  • Schiff base

ASJC Scopus subject areas

  • Chemistry(all)

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