Synthesis and antibacterial activities of 1,3,4-oxadiazole derivatives containing 5-methylisoxazole moiety

Xin Ping Hui, Chang Hu Chu, Zi Yi Zhang, Qin Wang, Qi Zhang

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

5-(5-Methylisoxazol-3-yl)-4-substituted aminomethyl-2-thio-1,3,4-oxadiazoles 3a-e and 4-acetyl-2-(5-methylisoxazol-3-yl)-5-substituted-1,3,4-oxadiazoles 5a-c have been synthesized by Mannich reaction of 5-(5-methylisoxazol-3-yl)-1,3,4-oxadiazol-2-thiol 2 with amines and cyclization of hydrazones with acetic anhydride, respectively. Moreover, 2-aryl-5-(5-methylisoxazol-3-yl)-1,3,4-oxadiazoles 6a-c have been obtained by direct condensation of 5-methylisoxazol-3-acetic acid hydrazizide with aromatic acid in the presence of POCl3. The compounds synthesized have been confirmed by their elemental analyses and spectral data. Their antibacterial activities have also been evaluated.

Original languageEnglish (US)
Pages (from-to)2176-2179
Number of pages4
JournalIndian Journal of Chemistry - Section B Organic and Medicinal Chemistry
Volume41
Issue number10
StatePublished - Oct 1 2002

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

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