Synovial sarcoma a DNA flow cytometric study

Adel K. El‐Naggar, Alberto G. Ayala, Fadi W. Abdul‐Karim, Donia McLemore, William W. Ballance, Lisa Garnsey, Jae Y. Ro, John G. Batsakis

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

The relationship between DNA content, clinicopathologic findings, and patient survival in synovial sarcoma was investigated. Patient age at diagnosis (P < 0.001), tumor size (P < 0.001), and ploidy status (P < 0.003) correlated significantly with patient survival. A marginally significant correlation between mitotic count and patient survival was also observed (P = 0.04). Histologic subtypes (monophasic) versus biphasic), mitotic count, and S-phase by flow cytometry had no significant influence on the clinical outcome of patients with synovial sarcoma in this study. The authors conclude that DNA ploidy analysis is a significant objective probe in the prognostication of patients with synovial sarcoma.

Original languageEnglish (US)
Pages (from-to)2295-2300
Number of pages6
JournalCancer
Volume65
Issue number10
DOIs
StatePublished - May 15 1990

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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