Synovial sarcoma a DNA flow cytometric study

Adel K. El‐Naggar; Alberto G. Ayala; Fadi W. Abdul‐Karim; Donia McLemore; William W. Ballance; Lisa Garnsey; Jae Y. Ro; John G. Batsakis

doi:10.1002/1097-0142(19900515)65:10<2295::AID-CNCR2820651022>3.0.CO;2-7

Synovial sarcoma a DNA flow cytometric study

Adel K. El‐Naggar, Alberto G. Ayala, Fadi W. Abdul‐Karim, Donia McLemore, William W. Ballance, Lisa Garnsey, Jae Y. Ro, John G. Batsakis

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

The relationship between DNA content, clinicopathologic findings, and patient survival in synovial sarcoma was investigated. Patient age at diagnosis (P < 0.001), tumor size (P < 0.001), and ploidy status (P < 0.003) correlated significantly with patient survival. A marginally significant correlation between mitotic count and patient survival was also observed (P = 0.04). Histologic subtypes (monophasic) versus biphasic), mitotic count, and S-phase by flow cytometry had no significant influence on the clinical outcome of patients with synovial sarcoma in this study. The authors conclude that DNA ploidy analysis is a significant objective probe in the prognostication of patients with synovial sarcoma.

Original language	English (US)
Pages (from-to)	2295-2300
Number of pages	6
Journal	Cancer
Volume	65
Issue number	10
DOIs	https://doi.org/10.1002/1097-0142(19900515)65:10<2295::AID-CNCR2820651022>3.0.CO;2-7
State	Published - May 15 1990

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1002/1097-0142(19900515)65:10<2295::AID-CNCR2820651022>3.0.CO;2-7

Cite this

@article{d5b36399f96c4c7392b3dd7afd4313ea,

title = "Synovial sarcoma a DNA flow cytometric study",

abstract = "The relationship between DNA content, clinicopathologic findings, and patient survival in synovial sarcoma was investigated. Patient age at diagnosis (P < 0.001), tumor size (P < 0.001), and ploidy status (P < 0.003) correlated significantly with patient survival. A marginally significant correlation between mitotic count and patient survival was also observed (P = 0.04). Histologic subtypes (monophasic) versus biphasic), mitotic count, and S-phase by flow cytometry had no significant influence on the clinical outcome of patients with synovial sarcoma in this study. The authors conclude that DNA ploidy analysis is a significant objective probe in the prognostication of patients with synovial sarcoma.",

author = "El‐Naggar, {Adel K.} and Ayala, {Alberto G.} and Abdul‐Karim, {Fadi W.} and Donia McLemore and Ballance, {William W.} and Lisa Garnsey and Ro, {Jae Y.} and Batsakis, {John G.}",

year = "1990",

month = may,

day = "15",

doi = "10.1002/1097-0142(19900515)65:10<2295::AID-CNCR2820651022>3.0.CO;2-7",

language = "English (US)",

volume = "65",

pages = "2295--2300",

journal = "Cancer",

issn = "0008-543X",

publisher = "Wiley",

number = "10",

}

TY - JOUR

T1 - Synovial sarcoma a DNA flow cytometric study

AU - El‐Naggar, Adel K.

AU - Ayala, Alberto G.

AU - Abdul‐Karim, Fadi W.

AU - McLemore, Donia

AU - Ballance, William W.

AU - Garnsey, Lisa

AU - Ro, Jae Y.

AU - Batsakis, John G.

PY - 1990/5/15

Y1 - 1990/5/15

N2 - The relationship between DNA content, clinicopathologic findings, and patient survival in synovial sarcoma was investigated. Patient age at diagnosis (P < 0.001), tumor size (P < 0.001), and ploidy status (P < 0.003) correlated significantly with patient survival. A marginally significant correlation between mitotic count and patient survival was also observed (P = 0.04). Histologic subtypes (monophasic) versus biphasic), mitotic count, and S-phase by flow cytometry had no significant influence on the clinical outcome of patients with synovial sarcoma in this study. The authors conclude that DNA ploidy analysis is a significant objective probe in the prognostication of patients with synovial sarcoma.

AB - The relationship between DNA content, clinicopathologic findings, and patient survival in synovial sarcoma was investigated. Patient age at diagnosis (P < 0.001), tumor size (P < 0.001), and ploidy status (P < 0.003) correlated significantly with patient survival. A marginally significant correlation between mitotic count and patient survival was also observed (P = 0.04). Histologic subtypes (monophasic) versus biphasic), mitotic count, and S-phase by flow cytometry had no significant influence on the clinical outcome of patients with synovial sarcoma in this study. The authors conclude that DNA ploidy analysis is a significant objective probe in the prognostication of patients with synovial sarcoma.

UR - http://www.scopus.com/inward/record.url?scp=0025281717&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025281717&partnerID=8YFLogxK

U2 - 10.1002/1097-0142(19900515)65:10<2295::AID-CNCR2820651022>3.0.CO;2-7

DO - 10.1002/1097-0142(19900515)65:10<2295::AID-CNCR2820651022>3.0.CO;2-7

M3 - Article

C2 - 2161280

AN - SCOPUS:0025281717

SN - 0008-543X

VL - 65

SP - 2295

EP - 2300

JO - Cancer

JF - Cancer

IS - 10

ER -

Synovial sarcoma a DNA flow cytometric study

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this