TY - GEN
T1 - Syndrome-based discrimination of single nucleotide polymorphism
AU - May, E. E.
AU - Dolan, P.
AU - Crozier, P.
AU - Brozik, S.
PY - 2006
Y1 - 2006
N2 - The ability to discriminate nucleic acid sequences is necessary for a wide variety of applications: high throughput screening, distinguishing genetically modified organisms (GMOs), molecular computing, differentiating biological markers, fingerprinting a specific sensor response for complex systems, etc. Hybridization-based target recognition and discrimination is central to the operation of nucleic acid sensor systems. Therefore developing a quantitative correlation between mishybridization events and sensor output is critical to the accurate interpretation of results. In this work, using experimental data produced by introducing single mutations (single nucleotide polymorphisms, SNPs) in the probe sequence of computational catalytic molecular beacons (deoxyribozyme gates) [1], we investigate coding theory algorithms for uniquely categorizing SNPs based on the calculation of syndromes.
AB - The ability to discriminate nucleic acid sequences is necessary for a wide variety of applications: high throughput screening, distinguishing genetically modified organisms (GMOs), molecular computing, differentiating biological markers, fingerprinting a specific sensor response for complex systems, etc. Hybridization-based target recognition and discrimination is central to the operation of nucleic acid sensor systems. Therefore developing a quantitative correlation between mishybridization events and sensor output is critical to the accurate interpretation of results. In this work, using experimental data produced by introducing single mutations (single nucleotide polymorphisms, SNPs) in the probe sequence of computational catalytic molecular beacons (deoxyribozyme gates) [1], we investigate coding theory algorithms for uniquely categorizing SNPs based on the calculation of syndromes.
KW - Coding theory
KW - DNA sensors
KW - Hybridization
KW - Single nucleotide polymorphism
KW - SNP
UR - http://www.scopus.com/inward/record.url?scp=34047190885&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34047190885&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2006.260747
DO - 10.1109/IEMBS.2006.260747
M3 - Conference contribution
C2 - 17947098
AN - SCOPUS:34047190885
SN - 1424400325
SN - 9781424400324
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 4548
EP - 4551
BT - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
T2 - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Y2 - 30 August 2006 through 3 September 2006
ER -