TY - JOUR
T1 - Synchrotron radiation techniques for nanotoxicology
AU - Li, Yu Feng
AU - Zhao, Jiating
AU - Qu, Ying
AU - Gao, Yuxi
AU - Guo, Zhenghang
AU - Liu, Zuoliang
AU - Zhao, Yuliang
AU - Chen, Chunying
N1 - Funding Information:
Funding: National Natural Science Foundation of China ( 11205168 , 11475196 ), Chinese Ministry of Science and Technology ( 2011CB933401 and 2012CB934003 ), National Major Scientific Instruments Development Project ( 2011YQ03013406 ), and International Science and Technology Cooperation Program of the Ministry of Science and Technology of China ( 2013DFG32340 ).
Funding Information:
Y-F Li gratefully acknowledges the support from K. C. Wong Education Foundation, Hong Kong and the CAS Youth Innovation Association, Chinese Academy of Sciences .
Publisher Copyright:
© 2015 Elsevier Inc.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2015
Y1 - 2015
N2 - Nanotoxicology studies the interactions of engineered nanomaterials with biological systems. Traditional in vitro and in vivo toxicological assays have been successfully employed. However, the toxicological mechanisms of nanoparticles might not be the same as those incurred in traditional molecular toxicology. Furthermore, how to realize in situ and real time measurements especially in the biological microenvironment is still a challenge. Synchrotron radiation, which is highly polarized and tunable, has been proved to play an indispensible role for nanotoxicology studies. In this review, the role of synchrotron radiation techniques is summarized in screening physicochemical characteristics, in vitro and in vivo behaviors, and ecotoxicological effects of engineered nanomaterials. From the Clinical Editor: The rapid gain in popularity of nanomaterials has also raised the concern of nanotoxicity, which needs to be assessed and addressed. In this comprehensive review, the authors outlined the underlying principles of using synchrotron radiation techniques for nanotoxicology studies and also in other scientific fields.
AB - Nanotoxicology studies the interactions of engineered nanomaterials with biological systems. Traditional in vitro and in vivo toxicological assays have been successfully employed. However, the toxicological mechanisms of nanoparticles might not be the same as those incurred in traditional molecular toxicology. Furthermore, how to realize in situ and real time measurements especially in the biological microenvironment is still a challenge. Synchrotron radiation, which is highly polarized and tunable, has been proved to play an indispensible role for nanotoxicology studies. In this review, the role of synchrotron radiation techniques is summarized in screening physicochemical characteristics, in vitro and in vivo behaviors, and ecotoxicological effects of engineered nanomaterials. From the Clinical Editor: The rapid gain in popularity of nanomaterials has also raised the concern of nanotoxicity, which needs to be assessed and addressed. In this comprehensive review, the authors outlined the underlying principles of using synchrotron radiation techniques for nanotoxicology studies and also in other scientific fields.
KW - Ecotoxicology
KW - In vitro
KW - In vivo
KW - Nanotoxicology
KW - Synchrotron radiation
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U2 - 10.1016/j.nano.2015.04.008
DO - 10.1016/j.nano.2015.04.008
M3 - Review article
C2 - 25933693
AN - SCOPUS:84937152852
VL - 11
SP - 1531
EP - 1549
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
SN - 1549-9634
IS - 6
ER -