Synchrotron infrared microspectroscopy for assessment of mutagenicity of metal implants

Miqin Zhang, Hoi Ying N Holman, Mauro Ferrari, Jennie C. Hunter-Cevera

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Abstract

A major concern in the development and implementation of metal implants for the clinical use is the assessment of material-induced mutagenesis. In this study we used synchrotron microspectroscopy in the mid-infrared region (4000-400 cm -1) to non-invasively assess the in situ human cell responses to metal surfaces. Specifically we examined the subtle genetic aberrations of cells as they responded to a range of metals commonly used in metal prosthetic devices. Relative band intensities and band intensity ratios for functional groups of biomolecules that are inherent to the experimental system were examined. The molecular components of the biomolecules as they were perturbed by the interactions with metals were investigated. These results demonstrate the potential use of synchrotron FTIR microspectroscopy to screen the mutagenicity of metal implants.

Original languageEnglish (US)
Title of host publicationMaterials Research Society Symposium - Proceedings
PublisherMaterials Research Society
Pages163-169
Number of pages7
Volume550
StatePublished - 1999
EventProceedings of the 1998 MRS Fall Meeting - The Symposium 'Advanced Catalytic Materials-1998' - Boston, MA, USA
Duration: Nov 30 1998Dec 3 1998

Other

OtherProceedings of the 1998 MRS Fall Meeting - The Symposium 'Advanced Catalytic Materials-1998'
CityBoston, MA, USA
Period11/30/9812/3/98

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials

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