Sustained remission from angioimmunoblastic T-cell lymphoma induced by alemtuzumab

Stephanie Halene, Arthur W. Zieske, Nancy Berliner

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Background: A 73-year-old woman presented with acute lower back pain, fever, chills and arthralgias. She had previously had a positive protein derivative test with a negative chest X-ray; her medical history was also remarkable for a mitral valve prolapse. Initial symptoms resolved spontaneously without therapy, but fever recurred with associated arthralgias, myalgias, diffuse and worsening lymphadenopathy, splenomegaly, and bilateral pulmonary infiltrates. Investigations: Physical examination, blood and urine cultures, MRI of the spine, echocardiogram, extensive serologies, serum and urine protein electrophoresis, immunofixation electrophoresis, bone-marrow aspiration and biopsy with flow cytometry, cytogenetics, and gene rearrangement studies, CT scan of the chest, abdomen and pelvis, whole-body PET, and lymph-node biopsy for histological examination, immunohistochemistry, and gene rearrangement studies. Diagnosis: Angioimmunoblastic T-cell lymphoma. Management: Steroids (pre dnisone, methylprednisolone), levofloxacin, isoniazid with pyridoxine, ciclosporin A, methotrexate, alemtuzumab, broad-spectrum antibiotics, Pneumocystis carinii prophylaxis, vancomycin, and clindamycin.

Original languageEnglish (US)
Pages (from-to)165-168
Number of pages4
JournalNature Clinical Practice Oncology
Volume3
Issue number3
DOIs
StatePublished - Mar 1 2006

Keywords

  • Alemtuzumab
  • Angioimmunoblastic T-cell lymphoma
  • Angioimmunoblastic lymphadenopathy
  • Cytokine storm
  • Steroids

ASJC Scopus subject areas

  • Oncology

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