TY - JOUR
T1 - Sustained remission from angioimmunoblastic T-cell lymphoma induced by alemtuzumab
AU - Halene, Stephanie
AU - Zieske, Arthur
AU - Berliner, Nancy
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2006/3
Y1 - 2006/3
N2 - Background: A 73-year-old woman presented with acute lower back pain, fever, chills and arthralgias. She had previously had a positive protein derivative test with a negative chest X-ray; her medical history was also remarkable for a mitral valve prolapse. Initial symptoms resolved spontaneously without therapy, but fever recurred with associated arthralgias, myalgias, diffuse and worsening lymphadenopathy, splenomegaly, and bilateral pulmonary infiltrates. Investigations: Physical examination, blood and urine cultures, MRI of the spine, echocardiogram, extensive serologies, serum and urine protein electrophoresis, immunofixation electrophoresis, bone-marrow aspiration and biopsy with flow cytometry, cytogenetics, and gene rearrangement studies, CT scan of the chest, abdomen and pelvis, whole-body PET, and lymph-node biopsy for histological examination, immunohistochemistry, and gene rearrangement studies. Diagnosis: Angioimmunoblastic T-cell lymphoma. Management: Steroids (pre dnisone, methylprednisolone), levofloxacin, isoniazid with pyridoxine, ciclosporin A, methotrexate, alemtuzumab, broad-spectrum antibiotics, Pneumocystis carinii prophylaxis, vancomycin, and clindamycin.
AB - Background: A 73-year-old woman presented with acute lower back pain, fever, chills and arthralgias. She had previously had a positive protein derivative test with a negative chest X-ray; her medical history was also remarkable for a mitral valve prolapse. Initial symptoms resolved spontaneously without therapy, but fever recurred with associated arthralgias, myalgias, diffuse and worsening lymphadenopathy, splenomegaly, and bilateral pulmonary infiltrates. Investigations: Physical examination, blood and urine cultures, MRI of the spine, echocardiogram, extensive serologies, serum and urine protein electrophoresis, immunofixation electrophoresis, bone-marrow aspiration and biopsy with flow cytometry, cytogenetics, and gene rearrangement studies, CT scan of the chest, abdomen and pelvis, whole-body PET, and lymph-node biopsy for histological examination, immunohistochemistry, and gene rearrangement studies. Diagnosis: Angioimmunoblastic T-cell lymphoma. Management: Steroids (pre dnisone, methylprednisolone), levofloxacin, isoniazid with pyridoxine, ciclosporin A, methotrexate, alemtuzumab, broad-spectrum antibiotics, Pneumocystis carinii prophylaxis, vancomycin, and clindamycin.
KW - Alemtuzumab
KW - Angioimmunoblastic T-cell lymphoma
KW - Angioimmunoblastic lymphadenopathy
KW - Cytokine storm
KW - Steroids
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U2 - 10.1038/ncponc0430
DO - 10.1038/ncponc0430
M3 - Article
C2 - 16520806
AN - SCOPUS:33645379106
SN - 1743-4254
VL - 3
SP - 165
EP - 168
JO - Nature Clinical Practice Oncology
JF - Nature Clinical Practice Oncology
IS - 3
ER -