Sustained release of sodium deoxycholate from PLGA–PEG–PLGA thermosensitive polymer

Parisa Nasrollahi, Khosro Khajeh, Elnaz Tamjid, Mohammad Taleb, Masoud Soleimani, Guangjun Nie

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Delivery of the drugs to the target tissue and reducing their side effects on surrounding tissues is still a significant challenge for pharmaceutical scientists. The aim of this study was to investigate the suitability of PLGA–PEG–PLGA triblock copolymer as a matrix material for a sustained-release system of sodium deoxycholate (NaDC). The copolymer was synthesized by ring-opening polymerization reaction, using microwave irradiation and characterized by different techniques. It was shown that the introduction of NaDC to the PLGA–PEG–PLGA copolymer did not influence its inherent sol–gel transition behaviour, but increased the sol–gel transition. The results showed the appropriate NaDC/polymer interaction and the formation of NaDC/polymer-mixed micelle. The sustained release of NaDC from the copolymer lasted for 2 days. This release can be attributed to the formation of NaDC/polymer-mixed micelles and trapping NaDC in the copolymer matrix. The cytolytic efficacy of NaDC-loaded copolymer and sustained release of NaDC were investigated on human adipocytes. Overall a sustained-release formulation for NaDC can be used to study localized fat dissolution.

Original languageEnglish (US)
Pages (from-to)1170-1177
Number of pages8
JournalArtificial Cells, Nanomedicine and Biotechnology
Volume46
Issue numbersup2
DOIs
StatePublished - Nov 5 2018

Keywords

  • PLGA–PEG–PLGA copolymer
  • localized fat
  • sodium deoxycholate
  • thermosensitive

ASJC Scopus subject areas

  • Biotechnology
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Pharmaceutical Science

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