Sustained release of sodium deoxycholate from PLGA–PEG–PLGA thermosensitive polymer

Parisa Nasrollahi; Khosro Khajeh; Elnaz Tamjid; Mohammad Taleb; Masoud Soleimani; Guangjun Nie

doi:10.1080/21691401.2018.1481861

Sustained release of sodium deoxycholate from PLGA–PEG–PLGA thermosensitive polymer

Parisa Nasrollahi, Khosro Khajeh, Elnaz Tamjid, Mohammad Taleb, Masoud Soleimani, Guangjun Nie

Houston Methodist

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Delivery of the drugs to the target tissue and reducing their side effects on surrounding tissues is still a significant challenge for pharmaceutical scientists. The aim of this study was to investigate the suitability of PLGA–PEG–PLGA triblock copolymer as a matrix material for a sustained-release system of sodium deoxycholate (NaDC). The copolymer was synthesized by ring-opening polymerization reaction, using microwave irradiation and characterized by different techniques. It was shown that the introduction of NaDC to the PLGA–PEG–PLGA copolymer did not influence its inherent sol–gel transition behaviour, but increased the sol–gel transition. The results showed the appropriate NaDC/polymer interaction and the formation of NaDC/polymer-mixed micelle. The sustained release of NaDC from the copolymer lasted for 2 days. This release can be attributed to the formation of NaDC/polymer-mixed micelles and trapping NaDC in the copolymer matrix. The cytolytic efficacy of NaDC-loaded copolymer and sustained release of NaDC were investigated on human adipocytes. Overall a sustained-release formulation for NaDC can be used to study localized fat dissolution.

Original language	English (US)
Pages (from-to)	1170-1177
Number of pages	8
Journal	Artificial Cells, Nanomedicine and Biotechnology
Volume	46
Issue number	sup2
DOIs	https://doi.org/10.1080/21691401.2018.1481861
State	Published - Nov 5 2018

Keywords

PLGA–PEG–PLGA copolymer
localized fat
sodium deoxycholate
thermosensitive

ASJC Scopus subject areas

Biotechnology
Medicine (miscellaneous)
Biomedical Engineering
Pharmaceutical Science

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10.1080/21691401.2018.1481861

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title = "Sustained release of sodium deoxycholate from PLGA–PEG–PLGA thermosensitive polymer",

abstract = "Delivery of the drugs to the target tissue and reducing their side effects on surrounding tissues is still a significant challenge for pharmaceutical scientists. The aim of this study was to investigate the suitability of PLGA–PEG–PLGA triblock copolymer as a matrix material for a sustained-release system of sodium deoxycholate (NaDC). The copolymer was synthesized by ring-opening polymerization reaction, using microwave irradiation and characterized by different techniques. It was shown that the introduction of NaDC to the PLGA–PEG–PLGA copolymer did not influence its inherent sol–gel transition behaviour, but increased the sol–gel transition. The results showed the appropriate NaDC/polymer interaction and the formation of NaDC/polymer-mixed micelle. The sustained release of NaDC from the copolymer lasted for 2 days. This release can be attributed to the formation of NaDC/polymer-mixed micelles and trapping NaDC in the copolymer matrix. The cytolytic efficacy of NaDC-loaded copolymer and sustained release of NaDC were investigated on human adipocytes. Overall a sustained-release formulation for NaDC can be used to study localized fat dissolution.",

keywords = "PLGA–PEG–PLGA copolymer, localized fat, sodium deoxycholate, thermosensitive",

author = "Parisa Nasrollahi and Khosro Khajeh and Elnaz Tamjid and Mohammad Taleb and Masoud Soleimani and Guangjun Nie",

note = "Funding Information: The authors thank the research council of Tarbiat Modares University and National Center for Nanoscience and Technology (NCNST) of China for the financial support of this investigation. Publisher Copyright: {\textcopyright} 2018, {\textcopyright} 2018 Informa UK Limited, trading as Taylor & Francis Group. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",

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AU - Nasrollahi, Parisa

AU - Khajeh, Khosro

AU - Tamjid, Elnaz

AU - Taleb, Mohammad

AU - Soleimani, Masoud

AU - Nie, Guangjun

N1 - Funding Information: The authors thank the research council of Tarbiat Modares University and National Center for Nanoscience and Technology (NCNST) of China for the financial support of this investigation. Publisher Copyright: © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2018/11/5

Y1 - 2018/11/5

N2 - Delivery of the drugs to the target tissue and reducing their side effects on surrounding tissues is still a significant challenge for pharmaceutical scientists. The aim of this study was to investigate the suitability of PLGA–PEG–PLGA triblock copolymer as a matrix material for a sustained-release system of sodium deoxycholate (NaDC). The copolymer was synthesized by ring-opening polymerization reaction, using microwave irradiation and characterized by different techniques. It was shown that the introduction of NaDC to the PLGA–PEG–PLGA copolymer did not influence its inherent sol–gel transition behaviour, but increased the sol–gel transition. The results showed the appropriate NaDC/polymer interaction and the formation of NaDC/polymer-mixed micelle. The sustained release of NaDC from the copolymer lasted for 2 days. This release can be attributed to the formation of NaDC/polymer-mixed micelles and trapping NaDC in the copolymer matrix. The cytolytic efficacy of NaDC-loaded copolymer and sustained release of NaDC were investigated on human adipocytes. Overall a sustained-release formulation for NaDC can be used to study localized fat dissolution.

AB - Delivery of the drugs to the target tissue and reducing their side effects on surrounding tissues is still a significant challenge for pharmaceutical scientists. The aim of this study was to investigate the suitability of PLGA–PEG–PLGA triblock copolymer as a matrix material for a sustained-release system of sodium deoxycholate (NaDC). The copolymer was synthesized by ring-opening polymerization reaction, using microwave irradiation and characterized by different techniques. It was shown that the introduction of NaDC to the PLGA–PEG–PLGA copolymer did not influence its inherent sol–gel transition behaviour, but increased the sol–gel transition. The results showed the appropriate NaDC/polymer interaction and the formation of NaDC/polymer-mixed micelle. The sustained release of NaDC from the copolymer lasted for 2 days. This release can be attributed to the formation of NaDC/polymer-mixed micelles and trapping NaDC in the copolymer matrix. The cytolytic efficacy of NaDC-loaded copolymer and sustained release of NaDC were investigated on human adipocytes. Overall a sustained-release formulation for NaDC can be used to study localized fat dissolution.

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Sustained release of sodium deoxycholate from PLGA–PEG–PLGA thermosensitive polymer

Abstract

Keywords

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