TY - JOUR
T1 - Sustained-release methylphenidate for cognitive impairment in HIV-1-infected drug abusers
T2 - A pilot study
AU - Van Dyck, Christopher H.
AU - McMahon, Thomas J.
AU - Rosen, Marc I.
AU - O'Malley, Stephanie S.
AU - O'Connor, Patrick G.
AU - Lin, C. Huie
AU - Pearsall, H. Rowland
AU - Woods, Scott W.
AU - Kosten, Thomas R.
PY - 1997
Y1 - 1997
N2 - Other investigators have reported clinical improvement from psychostimulant drugs in patients with HIV-1-related cognitive impairment. However, no previous research has substantiated this claim by using a controlled study design. We examined the efficacy of sustained-release methylphenidate (MSR) in a sample of substance abusers with HIV-1-related cognitive impairment. Eight HIV-1-infected methadone patients with impaired neuropsychological test performance participated in an inpatient double-blind placebo-controlled crossover trial of MSR 20-40 mg/day. On a composite neuropsychological measure, patients improved significant from baseline during MSR but not placebo treatment. Nevertheless, MSR performance did not differ significantly from placebo performance. Patients appeared to improve as a function of time, regardless of sequence, with somewhat more improvement during MSR than placebo treatment.
AB - Other investigators have reported clinical improvement from psychostimulant drugs in patients with HIV-1-related cognitive impairment. However, no previous research has substantiated this claim by using a controlled study design. We examined the efficacy of sustained-release methylphenidate (MSR) in a sample of substance abusers with HIV-1-related cognitive impairment. Eight HIV-1-infected methadone patients with impaired neuropsychological test performance participated in an inpatient double-blind placebo-controlled crossover trial of MSR 20-40 mg/day. On a composite neuropsychological measure, patients improved significant from baseline during MSR but not placebo treatment. Nevertheless, MSR performance did not differ significantly from placebo performance. Patients appeared to improve as a function of time, regardless of sequence, with somewhat more improvement during MSR than placebo treatment.
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U2 - 10.1176/jnp.9.1.29
DO - 10.1176/jnp.9.1.29
M3 - Article
C2 - 9017526
AN - SCOPUS:0031028945
SN - 0895-0172
VL - 9
SP - 29
EP - 36
JO - Journal of Neuropsychiatry and Clinical Neurosciences
JF - Journal of Neuropsychiatry and Clinical Neurosciences
IS - 1
ER -