Survival outcomes of primary intraocular lymphoma a single-institution experience

Michelle M. Kim, Bouthaina S. Dabaja, Jeffrey Medeiros, Stella Kim, Pamela Allen, Patricia Chevez-Barrios, Dan S. Gombos, Nathan Fowler

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

OBJECTIVES: We report the clinical outcomes of 22 patients with primary intraocular lymphoma (PIOL) treated over a 15-year period. MATERIALS AND METHODS: Patients with confirmed PIOL by central pathology review treated from 1994 to 2010 with isolated ocular (N=13) or central nervous system (CNS) plus ocular involvement (N=9) were included. Intraocular and CNS failure-free survival, relapse-free survival, and overall survival outcomes were analyzed. RESULTS: Median follow-up was 29.0 (range, 10.2 to 96.4) months. Sixteen patients (9 with isolated ocular, 7 with ocular and CNS disease) received combined modality therapy (CMT) consisting of systemic chemotherapy (usually high-dose methotrexate based) and orbital +/- whole-brain radiation. Two patients were treated with chemotherapy and 4 with local ocular therapy alone. Among patients with isolated ocular versus CNS involvement, CNS failure-free survival was 79% versus 57%, and intraocular failures were 62% versus 78% at 24 months. Median relapse-free survival was 34.0 versus 21.3 months (P=0.368), and overall survival 43.4 versus 30.3 months (P=0.744), respectively. Three patients treated with CMT (2 with isolated ocular and 1 with CNS involvement) with >1-year follow-up alive at the time of analysis never relapsed, and one remains disease-free >4.5 years after treatment. CONCLUSIONS: In this series of patients with PIOL+/- CNS disease, CNS and intraocular relapse were common. A trend toward better survival was seen among patients with isolated ocular presentation, and a limited number of long-term disease-free survivors seen after CMT.

Original languageEnglish (US)
Pages (from-to)109-113
Number of pages5
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume39
Issue number2
DOIs
StatePublished - 2016

Keywords

  • Primary intraocular lymphoma
  • Single-institution
  • Survival outcomes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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