Survival outcomes in patients with primary cardiac sarcoma in the United States

Kanhua Yin, Rongkui Luo, Yaguang Wei, Fenglei Wang, Yiwen Zhang, Karl J. Karlson, Zhiqi Zhang, Michael J. Reardon, Nikola Dobrilovic

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Objective: We aim to evaluate the survival outcomes of primary cardiac sarcoma in a US nationwide cancer database. Methods: The Surveillance, Epidemiology, and End Results database was queried to identify patients with primary cardiac sarcoma from 1973 to 2015. Kaplan–Meier analysis and log-rank tests were performed to compare overall survival for subpopulations, stratified on year at diagnosis (dichotomized into 2 periods: 1973-2005 and 2006-2015), pathological types, whether patients were treated with surgery or not, and surgery and chemotherapy combinations. Multivariable Cox regression was performed to estimate the adjusted hazard ratios and 95% confidence intervals of potentially clinically important factors. Results: A total of 442 patients (mean age, 47.2 ± 18.7 years; male 52.0%) were identified. Most patients were white (78.1%) and diagnosed at age 20 to 60 years (70.2%). Angiosarcoma (43.2%) was the most common histologic type. Overall, the median survival was 7 months, and the 1-, 3-, and 5-year survivals were 40.7%, 15.6%, and 9.8%, respectively. Patients who were diagnosed within the recent decade (2006-2015) did not achieve a better overall survival (P =.13). Surgery (adjusted hazard ratio, 0.49; 95% confidence interval, 0.37-0.64; P <.001) and chemotherapy (adjusted hazard ratio, 0.70; 95% confidence interval, 0.54-0.92; P =.009) were independently associated with improved overall survival. Increasing age (adjusted hazard ratio of 5-year increment, 1.07; 95% confidence interval, 1.04-1.11; P <.001) was independently associated with worse survival. Conclusions: At the population level, primary cardiac sarcoma has a poor prognosis. Both surgery and chemotherapy are associated with improved survival, whereas increasing age at diagnosis was associated with worse survival.

Original languageEnglish (US)
Pages (from-to)107-115.e2
JournalJournal of Thoracic and Cardiovascular Surgery
Issue number1
StatePublished - Jul 2021


  • SEER
  • primary cardiac sarcoma
  • survival

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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