Survey of H2-antagonist usage in acute upper gastrointestinal hemorrhage

Bankim D. Bhatt, Frank V. Meriano, Ted L. Phipps, Hoi Ho, Marc J. Zuckerman

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

H2-antagonists are frequently used in the management of upper gastrointestinal (UGI) hemorrhage despite their lack of proven efficacy. In order to determine the pattern of H2-antagonist usage for this indication, we retrospectively reviewed the charts of 137 patients admitted with acute UGI bleeding over a 1-year period at two teaching hospitals in West Texas. An H2-antagonist was ordered in 89% of patients (77% intravenous, 12% oral). It was administered within 2 h of admission in 25% of these patients, within 4 h in 54%, and within 8 h in 78%. An H2-antagonist was ordered among the initial six orders in 49% and among the initial 10 orders in 77% of patients. Considering orders for specific therapies, an H2-antagonist was in the initial three orders in 60% of patients and among the initial six orders in 97%. Of the patients who were prescribed an H2-antagonist and who also had upper endoscopy, the drug was ordered prior to endoscopy in 86%. This review of H2-antagonist usage in the management of acute UGI bleeding has identified a prescribing pattern of writing for these drugs early in the sequence of order writing, with the drugs being given early in the course of hospitalization.

Original languageEnglish (US)
Pages (from-to)14-16
Number of pages3
JournalJournal of Clinical Gastroenterology
Volume12
Issue number1
DOIs
StatePublished - Jan 1 1990

Keywords

  • cimetidine
  • gastrointestinal hemorrhage
  • H-antagonists
  • ranitidine
  • UGI bleeding

ASJC Scopus subject areas

  • Gastroenterology

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