TY - JOUR
T1 - "Surgical" Abdomen in a Patient with Chronic Lymphocytic Leukemia
T2 - A Case of Acquired Angioedema
AU - Jung, Moonjung
AU - Rice, Lawrence
PY - 2011/12
Y1 - 2011/12
N2 - Introduction: Acquired angioedema (AAE), an acquired deficiency of C1esterase inhibitor, is a medically treatable condition which can cause severe abdominal pain mimicking an acute surgical abdomen. This disorder is strongly associated with chronic lymphocytic leukemia (CLL) and other indolent lymphoplasmacytic disorders. Discussion: We describe a patient with known CLL who developed incapacitating, recurrent severe abdominal pains, culminating in partial bowel resection. Signs, symptoms, laboratory and pathologic findings demonstrated AAE. Conclusion: Wider appreciation of the possibility of AAE, particularly in patients with lymphoproliferative disorders, could lead to preventive therapy and spare unnecessary surgery. This is more important now that more effective medical therapies are available.
AB - Introduction: Acquired angioedema (AAE), an acquired deficiency of C1esterase inhibitor, is a medically treatable condition which can cause severe abdominal pain mimicking an acute surgical abdomen. This disorder is strongly associated with chronic lymphocytic leukemia (CLL) and other indolent lymphoplasmacytic disorders. Discussion: We describe a patient with known CLL who developed incapacitating, recurrent severe abdominal pains, culminating in partial bowel resection. Signs, symptoms, laboratory and pathologic findings demonstrated AAE. Conclusion: Wider appreciation of the possibility of AAE, particularly in patients with lymphoproliferative disorders, could lead to preventive therapy and spare unnecessary surgery. This is more important now that more effective medical therapies are available.
KW - Acquired angioedema
KW - Autoimmunity
KW - C1 inhibitor deficiency
KW - Chronic lymphocytic leukemia
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U2 - 10.1007/s11605-011-1718-0
DO - 10.1007/s11605-011-1718-0
M3 - Article
C2 - 21997434
AN - SCOPUS:81355148606
VL - 15
SP - 2262
EP - 2266
JO - Journal of Gastrointestinal Surgery
JF - Journal of Gastrointestinal Surgery
SN - 1091-255X
IS - 12
ER -