Surgery in recurrent epithelial ovarian cancer: Benefits on survival for patients with residual disease of 0.1-1 cm after secondary cytoreduction

Wen Juan Tian, Rong Jiang, Xi Cheng, Jie Tang, Yan Xing, Rong Yu Zang

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Aims: Recent retrospective trials stated that a benefit of surgery for recurrent ovarian cancer may be limited to patients in whom a complete cytoreduction (R0) could be achieved. Most of them pointed out there was no difference in survival between residual disease of 0.1-1 cm (R1) and >1 cm (R2). The aim of this study was to evaluate survival benefits from cytoreduction to R1. Methods: Between 2002 and 2006, 123 patients with recurrent epithelial ovarian cancer undergoing secondary cytoreduction were identified from tumor registry databases. Results: The median age at recurrence was 51 years (range: 28-84). Fifty-one (41.5%) patients had R0, 46 (37.4%) patients had R1, and 26 (21.1%) patients had R2 resection. The median survival of the entire cohort was 31.7 months, with an estimated 5-year survival of 31.1%. The median survival and estimated 5-year survival for patients with R1 were 31.1 months and 23.9%, and there were significant differences in survival when compared to 15.6 months and 6.4% in R2 (x2=7.45, P=0.006), 63.2 months (mean survival) and 54.4% in complete cytoreduction (x2=8.93, P=0.0028). Conclusions: Complete secondary cytoreduction is the strongest survival determinant in recurrent epithelial ovarian cancer, whereas patients with residual disease of 0.1-1 cm may also benefit from secondary cytoreduction.

Original languageEnglish (US)
Pages (from-to)244-250
Number of pages7
JournalJournal of Surgical Oncology
Volume101
Issue number3
DOIs
StatePublished - Mar 1 2010

Keywords

  • Ovarian cancer
  • Recurrence
  • Secondary cytoreduction
  • Surgery
  • Survival

ASJC Scopus subject areas

  • Surgery
  • Oncology

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