Surface Functionalization of Polymeric Nanoparticles with Umbilical Cord-Derived Mesenchymal Stem Cell Membrane for Tumor-Targeted Therapy

Na Yang, Yanping Ding, Yinlong Zhang, Bin Wang, Xiao Zhao, Keman Cheng, Yixin Huang, Mohammad Taleb, Jing Zhao, Wen Fei Dong, Lirong Zhang, Guangjun Nie

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Multiple cell plasma membranes have been utilized for surface functionalization of synthetic nanomaterials and construction of biomimetic drug delivery systems for cancer treatment. The natural characters and facile isolation of original cells facilitate the biomedical applications of plasma membranes in functionalizing nanocarriers. Human umbilical cord-derived mesenchymal stem cells (MSCs) have been identified to show tropism toward malignant lesions and have great advantages in ease of acquisition, low immunogenicity, and high proliferative ability. Here, we developed a poly(lactic-co-glycolic acid) (PLGA) nanoparticle with a layer of plasma membrane from umbilical cord MSC coating on the surface for tumor-Targeted delivery of chemotherapy. Functionalization of MSC plasma membrane significantly enhanced the cellular uptake efficiency of PLGA nanoparticles, the tumor cell killing efficacy of PLGA-encapsulated doxorubicin, and most importantly the tumor-Targeting and accumulation of the nanoparticles. As a result, this MSC-mimicking nanoformulation led to remarkable tumor growth inhibition and induced obvious apoptosis within tumor lesions. This study for the first time demonstrated the great potential of umbilical cord MSC plasma membranes in functionalizing nanocarriers with inherent tumor-homing features and the high feasibility of such biomimetic nanoformulations in cancer therapy.

Original languageEnglish (US)
Pages (from-to)22963-22973
Number of pages11
JournalACS Applied Materials and Interfaces
Volume10
Issue number27
DOIs
StatePublished - Jul 11 2018

Keywords

  • biomimetic nanoparticle
  • cancer therapy
  • plasma membrane
  • targeted drug delivery
  • umbilical cord mesenchymal stem cell

ASJC Scopus subject areas

  • Materials Science(all)

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