Surface engineering and patterning using parylene for biological applications

Christine P. Tan, Harold G. Craighead

Research output: Contribution to journalReview articlepeer-review

108 Scopus citations


Parylene is a family of chemically vapour deposited polymer with material properties that are attractive for biomedicine and nanobiotechnology. Chemically inert parylene "peel-off" stencils have been demonstrated for micropatterning biomolecular arrays with high uniformity, precise spatial control down to nanoscale resolution. Such micropatterned surfaces are beneficial in engineering biosensors and biological microenvironments. A variety of substituted precursors enables direct coating of functionalised parylenes onto biomedical implants and microfluidics, providing a convenient method for designing biocompatible and bioactive surfaces. This article will review the emerging role and applications of parylene as a biomaterial for surface chemical modification and provide a future outlook.

Original languageEnglish (US)
Pages (from-to)1803-1832
Number of pages30
Issue number3
StatePublished - 2010


  • [2.2]paracyclophane
  • Bioactive
  • Biomaterial
  • Biomolecular
  • Microarray
  • Microfluidic
  • Micropatterning
  • Nanobiotechnology
  • Parylene
  • Surface modification

ASJC Scopus subject areas

  • Materials Science(all)


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