Surface-engineered gold nanorods: Promising DNA vaccine adjuvant for HIV-1 treatment

Ligeng Xu; Ye Liu; Zhiyun Chen; Wei Li; Ying Liu; Liming Wang; Yong Liu; Xiaochun Wu; Yinglu Ji; Yuliang Zhao; Liying Ma; Yiming Shao; Chunying Chen

doi:10.1021/nl300027p

Surface-engineered gold nanorods: Promising DNA vaccine adjuvant for HIV-1 treatment

Ligeng Xu, Ye Liu, Zhiyun Chen, Wei Li, Ying Liu, Liming Wang, Yong Liu, Xiaochun Wu, Yinglu Ji, Yuliang Zhao, Liying Ma, Yiming Shao, Chunying Chen

Research output: Contribution to journal › Article › peer-review

276 Scopus citations

Abstract

With the intense international response to the AIDS pandemic, HIV vaccines have been extensively investigated but have failed due to issues of safety or efficacy in humans. Adjuvants for HIV/AIDS vaccines are under intense research but a rational design approach is still lacking. Nanomaterials represent an obvious opportunity in this field due to their unique physicochemical properties. Gold nanostructures are being actively studied as a promising and versatile platform for biomedical application. Herein, we report novel surface-engineered gold nanorods (NRs) used as promising DNA vaccine adjuvant for HIV treatment. We have exploited the effects of surface chemistry on the adjuvant activity of the gold nanorod by placing three kinds of molecules, that is, cetyltrimethylammonium bromide (CTAB), poly(diallydimethylammonium chloride) (PDDAC), and polyethyleneimine (PEI) on the surface of the nanorod. These PDDAC- or PEI-modified Au NRs can significantly promote cellular and humoral immunity as well as T cell proliferation through activating antigen-presenting cells if compared to naked HIV-1 Env plasmid DNA treatment in vivo. These findings have shed light on the rational design of low-toxic nanomaterials as a versatile platform for vaccine nanoadjuvants/delivery systems.

Original language	English (US)
Pages (from-to)	2003-2012
Number of pages	10
Journal	Nano Letters
Volume	12
Issue number	4
DOIs	https://doi.org/10.1021/nl300027p
State	Published - Apr 11 2012

Keywords

adjuvant
DNA vaccine
Gold nanorod
HIV-1
surface chemistry

ASJC Scopus subject areas

Condensed Matter Physics
Bioengineering
Chemistry(all)
Materials Science(all)
Mechanical Engineering

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10.1021/nl300027p

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title = "Surface-engineered gold nanorods: Promising DNA vaccine adjuvant for HIV-1 treatment",

abstract = "With the intense international response to the AIDS pandemic, HIV vaccines have been extensively investigated but have failed due to issues of safety or efficacy in humans. Adjuvants for HIV/AIDS vaccines are under intense research but a rational design approach is still lacking. Nanomaterials represent an obvious opportunity in this field due to their unique physicochemical properties. Gold nanostructures are being actively studied as a promising and versatile platform for biomedical application. Herein, we report novel surface-engineered gold nanorods (NRs) used as promising DNA vaccine adjuvant for HIV treatment. We have exploited the effects of surface chemistry on the adjuvant activity of the gold nanorod by placing three kinds of molecules, that is, cetyltrimethylammonium bromide (CTAB), poly(diallydimethylammonium chloride) (PDDAC), and polyethyleneimine (PEI) on the surface of the nanorod. These PDDAC- or PEI-modified Au NRs can significantly promote cellular and humoral immunity as well as T cell proliferation through activating antigen-presenting cells if compared to naked HIV-1 Env plasmid DNA treatment in vivo. These findings have shed light on the rational design of low-toxic nanomaterials as a versatile platform for vaccine nanoadjuvants/delivery systems.",

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AU - Xu, Ligeng

AU - Liu, Ye

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AU - Li, Wei

AU - Liu, Ying

AU - Wang, Liming

AU - Liu, Yong

AU - Wu, Xiaochun

AU - Ji, Yinglu

AU - Zhao, Yuliang

AU - Ma, Liying

AU - Shao, Yiming

AU - Chen, Chunying

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AB - With the intense international response to the AIDS pandemic, HIV vaccines have been extensively investigated but have failed due to issues of safety or efficacy in humans. Adjuvants for HIV/AIDS vaccines are under intense research but a rational design approach is still lacking. Nanomaterials represent an obvious opportunity in this field due to their unique physicochemical properties. Gold nanostructures are being actively studied as a promising and versatile platform for biomedical application. Herein, we report novel surface-engineered gold nanorods (NRs) used as promising DNA vaccine adjuvant for HIV treatment. We have exploited the effects of surface chemistry on the adjuvant activity of the gold nanorod by placing three kinds of molecules, that is, cetyltrimethylammonium bromide (CTAB), poly(diallydimethylammonium chloride) (PDDAC), and polyethyleneimine (PEI) on the surface of the nanorod. These PDDAC- or PEI-modified Au NRs can significantly promote cellular and humoral immunity as well as T cell proliferation through activating antigen-presenting cells if compared to naked HIV-1 Env plasmid DNA treatment in vivo. These findings have shed light on the rational design of low-toxic nanomaterials as a versatile platform for vaccine nanoadjuvants/delivery systems.

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Surface-engineered gold nanorods: Promising DNA vaccine adjuvant for HIV-1 treatment

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Keywords

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