TY - JOUR
T1 - Surface characteristics of nanocrystalline apatites
T2 - Effect of Mg surface enrichment on morphology, surface hydration species, and cationic environments
AU - Bertinetti, Luca
AU - Drouet, Christophe
AU - Combes, Christele
AU - Rey, Christian
AU - Tampieri, Anna
AU - Coluccia, Salvatore
AU - Martra, Gianmario
PY - 2009/5/19
Y1 - 2009/5/19
N2 - The incorporation of foreign ions, such as Mg2+ , exhibiting a biological activity for bone regeneration is presently considered as a promising route for increasing the bioactivity of bone-engineering scaffolds. In this work, the morphology, structure, and surface hydration of biomimetic nanocrystalline apatites were investigated before and after surface exchange with such Mg2+ ions, by combining chemical alterations (ion exchange, H2O- D2O exchanges) and physical examinations (Fourier transform infrared spectroscopy (FTIR) and high- resolution transmission electron microscopy (HRTEM)). HRTEM data suggested that the Mg2+ /Ca2+ exchange process did not affect the morphology and surface topology of the apatite nanocrystals significantly, while a new phase, likely a hydrated calcium and/or magnesium phosphate, was formed in small amount for high Mg concentrations. Near-infrared (NIR) and medium-infrared (MIR) spectroscopies indicated that the samples enriched with Mg2+ were found to retain more water at their surface than the Mg-free sample, both at the level of H 2O coordinated to cations and adsorbed in the form of multilayers. Additionally, the H-bonding network in defective subsurface layers was also noticeably modified, indicating that the Mg2+ /Ca2+ exchange involved was not limited to the surface. This work is intended to widen the present knowledge on Mg-enriched calcium phosphate-based bioactive materials intended for bone repair applications.
AB - The incorporation of foreign ions, such as Mg2+ , exhibiting a biological activity for bone regeneration is presently considered as a promising route for increasing the bioactivity of bone-engineering scaffolds. In this work, the morphology, structure, and surface hydration of biomimetic nanocrystalline apatites were investigated before and after surface exchange with such Mg2+ ions, by combining chemical alterations (ion exchange, H2O- D2O exchanges) and physical examinations (Fourier transform infrared spectroscopy (FTIR) and high- resolution transmission electron microscopy (HRTEM)). HRTEM data suggested that the Mg2+ /Ca2+ exchange process did not affect the morphology and surface topology of the apatite nanocrystals significantly, while a new phase, likely a hydrated calcium and/or magnesium phosphate, was formed in small amount for high Mg concentrations. Near-infrared (NIR) and medium-infrared (MIR) spectroscopies indicated that the samples enriched with Mg2+ were found to retain more water at their surface than the Mg-free sample, both at the level of H 2O coordinated to cations and adsorbed in the form of multilayers. Additionally, the H-bonding network in defective subsurface layers was also noticeably modified, indicating that the Mg2+ /Ca2+ exchange involved was not limited to the surface. This work is intended to widen the present knowledge on Mg-enriched calcium phosphate-based bioactive materials intended for bone repair applications.
UR - http://www.scopus.com/inward/record.url?scp=66249134934&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=66249134934&partnerID=8YFLogxK
U2 - 10.1021/la804230j
DO - 10.1021/la804230j
M3 - Article
C2 - 19281274
AN - SCOPUS:66249134934
SN - 0743-7463
VL - 25
SP - 5647
EP - 5654
JO - Langmuir
JF - Langmuir
IS - 10
ER -