Surface binding site density determination in a nanofluidic immunoassay device achieving total capture

Casey J. Galvin; Kentaro Shirai; Masaya Kakuta; Amy Q. Shen

Surface binding site density determination in a nanofluidic immunoassay device achieving total capture

Casey J. Galvin, Kentaro Shirai, Masaya Kakuta, Amy Q. Shen

Houston Methodist

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We demonstrate a nanofluidic immunoassay operating in a convection limited, wave propagating regime. We visualize directly the propagating wavefront of analyte along the nanochannel. Applying a continuum model to this system allows an estimation of the binding site density of target analyte in the enclosed nanochannel.

Original language	English (US)
Title of host publication	21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Publisher	Chemical and Biological Microsystems Society
Pages	1285-1286
Number of pages	2
ISBN (Electronic)	9780692941836
State	Published - Jan 1 2020
Event	21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States Duration: Oct 22 2017 → Oct 26 2017

Other

Other	21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Country/Territory	United States
City	Savannah
Period	10/22/17 → 10/26/17

Keywords

Binding Site Density
Convection Limited
Immunoassay
Nanofluidics

ASJC Scopus subject areas

Chemical Engineering (miscellaneous)
Bioengineering

Cite this

Surface binding site density determination in a nanofluidic immunoassay device achieving total capture. / Galvin, Casey J.; Shirai, Kentaro; Kakuta, Masaya et al.
21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017. Chemical and Biological Microsystems Society, 2020. p. 1285-1286.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Galvin, CJ, Shirai, K, Kakuta, M & Shen, AQ 2020, Surface binding site density determination in a nanofluidic immunoassay device achieving total capture. in 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017. Chemical and Biological Microsystems Society, pp. 1285-1286, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017, Savannah, United States, 10/22/17.

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abstract = "We demonstrate a nanofluidic immunoassay operating in a convection limited, wave propagating regime. We visualize directly the propagating wavefront of analyte along the nanochannel. Applying a continuum model to this system allows an estimation of the binding site density of target analyte in the enclosed nanochannel.",

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AU - Galvin, Casey J.

AU - Shirai, Kentaro

AU - Kakuta, Masaya

AU - Shen, Amy Q.

PY - 2020/1/1

Y1 - 2020/1/1

N2 - We demonstrate a nanofluidic immunoassay operating in a convection limited, wave propagating regime. We visualize directly the propagating wavefront of analyte along the nanochannel. Applying a continuum model to this system allows an estimation of the binding site density of target analyte in the enclosed nanochannel.

AB - We demonstrate a nanofluidic immunoassay operating in a convection limited, wave propagating regime. We visualize directly the propagating wavefront of analyte along the nanochannel. Applying a continuum model to this system allows an estimation of the binding site density of target analyte in the enclosed nanochannel.

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KW - Convection Limited

KW - Immunoassay

KW - Nanofluidics

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M3 - Conference contribution

SP - 1285

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BT - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

PB - Chemical and Biological Microsystems Society

T2 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Y2 - 22 October 2017 through 26 October 2017

ER -

Surface binding site density determination in a nanofluidic immunoassay device achieving total capture

Abstract

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Keywords

ASJC Scopus subject areas

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