Surface binding site density determination in a nanofluidic immunoassay device achieving total capture

Casey J. Galvin, Kentaro Shirai, Masaya Kakuta, Amy Q. Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We demonstrate a nanofluidic immunoassay operating in a convection limited, wave propagating regime. We visualize directly the propagating wavefront of analyte along the nanochannel. Applying a continuum model to this system allows an estimation of the binding site density of target analyte in the enclosed nanochannel.

Original languageEnglish (US)
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PublisherChemical and Biological Microsystems Society
Pages1285-1286
Number of pages2
ISBN (Electronic)9780692941836
StatePublished - Jan 1 2020
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
Duration: Oct 22 2017Oct 26 2017

Other

Other21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
CountryUnited States
CitySavannah
Period10/22/1710/26/17

Keywords

  • Binding Site Density
  • Convection Limited
  • Immunoassay
  • Nanofluidics

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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