Abstract
The poor stability of therapeutic peptides in physiological environments hampers their therapeutic efficacy. In this work, a strategy of supramolecular peptide therapeutics (SPT) was proposed for the improvement of the stability and anticancer efficacy of the peptides in vivo. N-Terminal phenylalanine-containing cytotoxic peptides were carried in the cucurbit[7]uril-containing polymer through host–guest interactions between the phenylalanine and cucurbit[7]uril, generating the supramolecular peptide complex with high peptide encapsulation efficiency (> 97%). The formation of the supramolecular peptide complex reserved the biological activities of the peptide, presenting prolonged blood circulation and improved anticancer efficacy. This SPT strategy might provide a cucurbituril- and phenylalanine-functionalized approach for the design and the development of peptide-based pharmaceuticals.
Original language | English (US) |
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Pages (from-to) | 739-748 |
Number of pages | 10 |
Journal | CCS Chemistry |
Volume | 2 |
Issue number | 6 |
DOIs | |
State | Published - Dec 2020 |
Keywords
- Anticancer peptide
- Cancer therapy
- Cucurbit[7]uril
- Drug delivery
- Supramolecular chemistry
ASJC Scopus subject areas
- Chemistry(all)