Supramolecular peptide therapeutics: Host–guest interaction-assisted systemic delivery of anticancer peptides

Hua Wang, Ya Qiong Yan, Yu Yi, Zi Yu Wei, Hao Chen, Jiang Fei Xu, Hao Wang, Yuliang Zhao, Xi Zhang

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

The poor stability of therapeutic peptides in physiological environments hampers their therapeutic efficacy. In this work, a strategy of supramolecular peptide therapeutics (SPT) was proposed for the improvement of the stability and anticancer efficacy of the peptides in vivo. N-Terminal phenylalanine-containing cytotoxic peptides were carried in the cucurbit[7]uril-containing polymer through host–guest interactions between the phenylalanine and cucurbit[7]uril, generating the supramolecular peptide complex with high peptide encapsulation efficiency (> 97%). The formation of the supramolecular peptide complex reserved the biological activities of the peptide, presenting prolonged blood circulation and improved anticancer efficacy. This SPT strategy might provide a cucurbituril- and phenylalanine-functionalized approach for the design and the development of peptide-based pharmaceuticals.

Original languageEnglish (US)
Pages (from-to)739-748
Number of pages10
JournalCCS Chemistry
Volume2
Issue number6
DOIs
StatePublished - Dec 2020

Keywords

  • Anticancer peptide
  • Cancer therapy
  • Cucurbit[7]uril
  • Drug delivery
  • Supramolecular chemistry

ASJC Scopus subject areas

  • Chemistry(all)

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