Suprachoroidal space alterations following delivery of triamcinolone acetonide: Post-hoc analysis of the phase 1/2 HULK study of patients with diabetic macular edema

Shaun I.R. Lampen, Rahul N. Khurana, Glenn Noronha, David M. Brown, Charles C. Wykoff

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

BACKGROUND AND OBJECTIVE: To study anatomic changes in the suprachoroidal space (SCS) following suprachoroidal injection of CLS-TA, triamcinolone acetonide injectable suspension. PATIENTS AND METHODS: Eyes with diabetic macular edema receiving CLS-TA were imaged serially using anterior segment spectral-domain optical coherence tomography to examine the SCS. RESULTS: At the final imaging session, the SCS was not significantly different in study eyes (n = 14; 8.4 µm) compared to fellow eyes (n = 10; 8.1 µm; P = .698). Two eyes were imaged immediately before and 30 minutes after suprachoroidal injections; in these eyes, mean suprachoroidal width increased significantly following CLS-TA injection, 9.9 µm to 75.1 µm (P < .001), and subsequently returned to 14.9 µm 1 month after the final injection (P = .221). CONCLUSION: Suprachoroidal CLS-TA injection caused a measurable increase in the SCS, which returned to preinjection levels by 1 month following injection with no apparent lasting impact on SCS anatomy.

Original languageEnglish (US)
Pages (from-to)692-697
Number of pages6
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume49
Issue number9
DOIs
StatePublished - Sep 1 2018

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

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