TY - JOUR
T1 - Suppressor cell clones specific for ultraviolet radiation-induced tumors
T2 - Function and surface proteins
AU - Trial, Joann
AU - Mcintyre, Bradley W.
PY - 1990/10/1
Y1 - 1990/10/1
N2 - Lymphocytes were cloned from animals bearing UV-induced skin tumors. These cells were 1-J+, CD4-, CD8-, and had become growth factor independent. Extracts, but not supernatants, of these clones suppressed primary immune reactions in vitro against UV-induced tumors, but not methylchol-anthrene-induced tumors. The cells therefore had the functional characteristics of afferent suppressor T cells directed against a common Ag on UV-induced tumors. Surface iodination of the clones revealed an extremely low level expression of molecules that might be TCR or related molecules.
AB - Lymphocytes were cloned from animals bearing UV-induced skin tumors. These cells were 1-J+, CD4-, CD8-, and had become growth factor independent. Extracts, but not supernatants, of these clones suppressed primary immune reactions in vitro against UV-induced tumors, but not methylchol-anthrene-induced tumors. The cells therefore had the functional characteristics of afferent suppressor T cells directed against a common Ag on UV-induced tumors. Surface iodination of the clones revealed an extremely low level expression of molecules that might be TCR or related molecules.
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M3 - Article
C2 - 1975821
AN - SCOPUS:0025096453
SN - 0022-1767
VL - 145
SP - 2044
EP - 2049
JO - Journal of Immunology
JF - Journal of Immunology
IS - 7
ER -