Suppression of miRNA-708 by Polycomb Group Promotes Metastases by Calcium-Induced Cell Migration

Research output: Contribution to journalArticle

Seongho Ryu, Kevin McDonnell, Hyejin Choi, Dingcheng Gao, Mary Hahn, Natasha Joshi, Sun Mi Park, Raul Catena, Yoonkyung Do, Jacqueline Brazin, Linda T. Vahdat, Randi B. Silver, Vivek Mittal

The progression of cancer to metastatic disease is a major cause of death. We identified miR-708 being transcriptionally repressed by polycomb repressor complex 2-induced H3K27 trimethylation in metastatic breast cancer. miR-708 targets the endoplasmic reticulum protein neuronatin to decrease intracellular calcium level, resulting in reduction of activation of ERK and FAK, decreased cell migration, and impaired metastases. Ectopic expression of neuronatin refractory to suppression by miR-708 rescued cell migration and metastasis defects. In patients with breast cancer, miR-708 expression was decreased in lymph node and distal metastases, suggesting a metastasis-suppressive role. Our findings uncover a mechanistic role for miR-708 in metastasis and provide a rationale for developing miR-708 as a therapeutic agent against metastatic breast cancer.

Original languageEnglish
Pages (from-to)63-76
Number of pages14
JournalCancer Cell
Volume23
Issue number1
DOIs
StatePublished - Jan 14 2013

PMID: 23328481

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Suppression of miRNA-708 by Polycomb Group Promotes Metastases by Calcium-Induced Cell Migration. / Ryu, Seongho; McDonnell, Kevin; Choi, Hyejin; Gao, Dingcheng; Hahn, Mary; Joshi, Natasha; Park, Sun Mi; Catena, Raul; Do, Yoonkyung; Brazin, Jacqueline; Vahdat, Linda T.; Silver, Randi B.; Mittal, Vivek.

In: Cancer Cell, Vol. 23, No. 1, 14.01.2013, p. 63-76.

Research output: Contribution to journalArticle

Harvard

Ryu, S, McDonnell, K, Choi, H, Gao, D, Hahn, M, Joshi, N, Park, SM, Catena, R, Do, Y, Brazin, J, Vahdat, LT, Silver, RB & Mittal, V 2013, 'Suppression of miRNA-708 by Polycomb Group Promotes Metastases by Calcium-Induced Cell Migration' Cancer Cell, vol. 23, no. 1, pp. 63-76. https://doi.org/10.1016/j.ccr.2012.11.019

APA

Ryu, S., McDonnell, K., Choi, H., Gao, D., Hahn, M., Joshi, N., ... Mittal, V. (2013). Suppression of miRNA-708 by Polycomb Group Promotes Metastases by Calcium-Induced Cell Migration. Cancer Cell, 23(1), 63-76. https://doi.org/10.1016/j.ccr.2012.11.019

Vancouver

Ryu S, McDonnell K, Choi H, Gao D, Hahn M, Joshi N et al. Suppression of miRNA-708 by Polycomb Group Promotes Metastases by Calcium-Induced Cell Migration. Cancer Cell. 2013 Jan 14;23(1):63-76. https://doi.org/10.1016/j.ccr.2012.11.019

Author

Ryu, Seongho ; McDonnell, Kevin ; Choi, Hyejin ; Gao, Dingcheng ; Hahn, Mary ; Joshi, Natasha ; Park, Sun Mi ; Catena, Raul ; Do, Yoonkyung ; Brazin, Jacqueline ; Vahdat, Linda T. ; Silver, Randi B. ; Mittal, Vivek. / Suppression of miRNA-708 by Polycomb Group Promotes Metastases by Calcium-Induced Cell Migration. In: Cancer Cell. 2013 ; Vol. 23, No. 1. pp. 63-76.

BibTeX

@article{216575a6c1f241538fe7374bdd4c416c,
title = "Suppression of miRNA-708 by Polycomb Group Promotes Metastases by Calcium-Induced Cell Migration",
abstract = "The progression of cancer to metastatic disease is a major cause of death. We identified miR-708 being transcriptionally repressed by polycomb repressor complex 2-induced H3K27 trimethylation in metastatic breast cancer. miR-708 targets the endoplasmic reticulum protein neuronatin to decrease intracellular calcium level, resulting in reduction of activation of ERK and FAK, decreased cell migration, and impaired metastases. Ectopic expression of neuronatin refractory to suppression by miR-708 rescued cell migration and metastasis defects. In patients with breast cancer, miR-708 expression was decreased in lymph node and distal metastases, suggesting a metastasis-suppressive role. Our findings uncover a mechanistic role for miR-708 in metastasis and provide a rationale for developing miR-708 as a therapeutic agent against metastatic breast cancer.",
author = "Seongho Ryu and Kevin McDonnell and Hyejin Choi and Dingcheng Gao and Mary Hahn and Natasha Joshi and Park, {Sun Mi} and Raul Catena and Yoonkyung Do and Jacqueline Brazin and Vahdat, {Linda T.} and Silver, {Randi B.} and Vivek Mittal",
year = "2013",
month = "1",
day = "14",
doi = "10.1016/j.ccr.2012.11.019",
language = "English",
volume = "23",
pages = "63--76",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "1",

}

RIS

TY - JOUR

T1 - Suppression of miRNA-708 by Polycomb Group Promotes Metastases by Calcium-Induced Cell Migration

AU - Ryu, Seongho

AU - McDonnell, Kevin

AU - Choi, Hyejin

AU - Gao, Dingcheng

AU - Hahn, Mary

AU - Joshi, Natasha

AU - Park, Sun Mi

AU - Catena, Raul

AU - Do, Yoonkyung

AU - Brazin, Jacqueline

AU - Vahdat, Linda T.

AU - Silver, Randi B.

AU - Mittal, Vivek

PY - 2013/1/14

Y1 - 2013/1/14

N2 - The progression of cancer to metastatic disease is a major cause of death. We identified miR-708 being transcriptionally repressed by polycomb repressor complex 2-induced H3K27 trimethylation in metastatic breast cancer. miR-708 targets the endoplasmic reticulum protein neuronatin to decrease intracellular calcium level, resulting in reduction of activation of ERK and FAK, decreased cell migration, and impaired metastases. Ectopic expression of neuronatin refractory to suppression by miR-708 rescued cell migration and metastasis defects. In patients with breast cancer, miR-708 expression was decreased in lymph node and distal metastases, suggesting a metastasis-suppressive role. Our findings uncover a mechanistic role for miR-708 in metastasis and provide a rationale for developing miR-708 as a therapeutic agent against metastatic breast cancer.

AB - The progression of cancer to metastatic disease is a major cause of death. We identified miR-708 being transcriptionally repressed by polycomb repressor complex 2-induced H3K27 trimethylation in metastatic breast cancer. miR-708 targets the endoplasmic reticulum protein neuronatin to decrease intracellular calcium level, resulting in reduction of activation of ERK and FAK, decreased cell migration, and impaired metastases. Ectopic expression of neuronatin refractory to suppression by miR-708 rescued cell migration and metastasis defects. In patients with breast cancer, miR-708 expression was decreased in lymph node and distal metastases, suggesting a metastasis-suppressive role. Our findings uncover a mechanistic role for miR-708 in metastasis and provide a rationale for developing miR-708 as a therapeutic agent against metastatic breast cancer.

UR - http://www.scopus.com/inward/record.url?scp=84872376809&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872376809&partnerID=8YFLogxK

U2 - 10.1016/j.ccr.2012.11.019

DO - 10.1016/j.ccr.2012.11.019

M3 - Article

VL - 23

SP - 63

EP - 76

JO - Cancer Cell

T2 - Cancer Cell

JF - Cancer Cell

SN - 1535-6108

IS - 1

ER -

ID: 3326505