Suppression of experimental myasthenia gravis by monoclonal antibodies against MHC peptide region involved in presentation of a pathogenic T-cell epitope

Nori Nakayashiki; Minako Oshima; Philip R. Deitiker; Tetsuo Ashizawa; M. Zouhair Atassi

doi:10.1016/S0165-5728(00)00199-5

Suppression of experimental myasthenia gravis by monoclonal antibodies against MHC peptide region involved in presentation of a pathogenic T-cell epitope

Nori Nakayashiki, Minako Oshima, Philip R. Deitiker, Tetsuo Ashizawa, M. Zouhair Atassi

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We have prepared monoclonal antibodies (mAbs) against an antigen-binding region of I-A, region 62-76 of I-Aβ^b, which is involved in the T-cell participation in the pathogenesis of EAMG. The mAbs reacted with its parent molecules and inhibited the proliferation of disease-related T-cells. Passive transfer of these mAbs suppressed the occurrence of clinical EAMG, which was accompanied by decreased T-cell and Ab responses to tAChR. The results indicated that blocking the function of disease-related MHC by targeting a disease-associated region on MHC molecules could be an effective, straightforward and feasible strategy for immunointervention in MG. Copyright (C) 2000 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	131-144
Number of pages	14
Journal	Journal of Neuroimmunology
Volume	105
Issue number	2
DOIs	https://doi.org/10.1016/S0165-5728(00)00199-5
State	Published - Jun 26 2000

Keywords

Antibodies
Antigen presentation
Autoimmunity
Immunotherapy
MHC

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

Access to Document

10.1016/S0165-5728(00)00199-5

Cite this

@article{45cc85baca534319ab6809ab121d6754,

title = "Suppression of experimental myasthenia gravis by monoclonal antibodies against MHC peptide region involved in presentation of a pathogenic T-cell epitope",

abstract = "We have prepared monoclonal antibodies (mAbs) against an antigen-binding region of I-A, region 62-76 of I-Aβb, which is involved in the T-cell participation in the pathogenesis of EAMG. The mAbs reacted with its parent molecules and inhibited the proliferation of disease-related T-cells. Passive transfer of these mAbs suppressed the occurrence of clinical EAMG, which was accompanied by decreased T-cell and Ab responses to tAChR. The results indicated that blocking the function of disease-related MHC by targeting a disease-associated region on MHC molecules could be an effective, straightforward and feasible strategy for immunointervention in MG. Copyright (C) 2000 Elsevier Science B.V.",

keywords = "Antibodies, Antigen presentation, Autoimmunity, Immunotherapy, MHC",

author = "Nori Nakayashiki and Minako Oshima and Deitiker, {Philip R.} and Tetsuo Ashizawa and Atassi, {M. Zouhair}",

note = "Funding Information: This work was supported by the Muscular Dystrophy Association. The support of the Welch Foundation, due to the award to M.Z.A. of the Robert A. Welch Chair of Chemistry, is also gratefully acknowledged. The authors thank Hai Tran and Ray Witt for their technical assistance. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.",

year = "2000",

month = jun,

day = "26",

doi = "10.1016/S0165-5728(00)00199-5",

language = "English (US)",

volume = "105",

pages = "131--144",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Suppression of experimental myasthenia gravis by monoclonal antibodies against MHC peptide region involved in presentation of a pathogenic T-cell epitope

AU - Nakayashiki, Nori

AU - Oshima, Minako

AU - Deitiker, Philip R.

AU - Ashizawa, Tetsuo

AU - Atassi, M. Zouhair

N1 - Funding Information: This work was supported by the Muscular Dystrophy Association. The support of the Welch Foundation, due to the award to M.Z.A. of the Robert A. Welch Chair of Chemistry, is also gratefully acknowledged. The authors thank Hai Tran and Ray Witt for their technical assistance. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.

PY - 2000/6/26

Y1 - 2000/6/26

N2 - We have prepared monoclonal antibodies (mAbs) against an antigen-binding region of I-A, region 62-76 of I-Aβb, which is involved in the T-cell participation in the pathogenesis of EAMG. The mAbs reacted with its parent molecules and inhibited the proliferation of disease-related T-cells. Passive transfer of these mAbs suppressed the occurrence of clinical EAMG, which was accompanied by decreased T-cell and Ab responses to tAChR. The results indicated that blocking the function of disease-related MHC by targeting a disease-associated region on MHC molecules could be an effective, straightforward and feasible strategy for immunointervention in MG. Copyright (C) 2000 Elsevier Science B.V.

AB - We have prepared monoclonal antibodies (mAbs) against an antigen-binding region of I-A, region 62-76 of I-Aβb, which is involved in the T-cell participation in the pathogenesis of EAMG. The mAbs reacted with its parent molecules and inhibited the proliferation of disease-related T-cells. Passive transfer of these mAbs suppressed the occurrence of clinical EAMG, which was accompanied by decreased T-cell and Ab responses to tAChR. The results indicated that blocking the function of disease-related MHC by targeting a disease-associated region on MHC molecules could be an effective, straightforward and feasible strategy for immunointervention in MG. Copyright (C) 2000 Elsevier Science B.V.

KW - Antibodies

KW - Antigen presentation

KW - Autoimmunity

KW - Immunotherapy

KW - MHC

UR - http://www.scopus.com/inward/record.url?scp=0034717830&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034717830&partnerID=8YFLogxK

U2 - 10.1016/S0165-5728(00)00199-5

DO - 10.1016/S0165-5728(00)00199-5

M3 - Article

C2 - 10742555

AN - SCOPUS:0034717830

VL - 105

SP - 131

EP - 144

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 2

ER -

Suppression of experimental myasthenia gravis by monoclonal antibodies against MHC peptide region involved in presentation of a pathogenic T-cell epitope

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this