TY - JOUR
T1 - Supported lipid bilayer/carbon nanotube hybrids
AU - Zhou, Xinjian
AU - Moran-Mirabal, Jose M.
AU - Craighead, Harold G.
AU - McEuen, Paul L.
N1 - Funding Information:
This work was supported by the Nanobiotechnology Center (NBTC), an STC Program of the National Science Foundation under Agreement No. ECS-9876771. J.M.M. thanks CONACyT for support through its graduate fellowship programme. Sample fabrication was performed at the Cornell Nanoscale Science & Technology Facility, a member of the National Nanotechnology Infrastructure Network, which is supported by the National Science Foundation (Grant ECS 03-35765). Supplementary information accompanies this paper on www.nature.com/naturenanotechnology. Correspondence and requests for materials should be addressed to X.Z. or P.L.M.
PY - 2007/3
Y1 - 2007/3
N2 - Carbon nanotube transistors combine molecular-scale dimensions with excellent electronic properties, offering unique opportunities for chemical and biological sensing. Here, we form supported lipid bilayers over single-walled carbon nanotube transistors. We first study the physical properties of the nanotube/supported lipid bilayer structure using fluorescence techniques. Whereas lipid molecules can diffuse freely across the nanotube, a membrane-bound protein (tetanus toxin) sees the nanotube as a barrier. Moreover, the size of the barrier depends on the diameter of the nanotube-with larger nanotubes presenting bigger obstacles to diffusion. We then demonstrate detection of protein binding (streptavidin) to the supported lipid bilayer using the nanotube transistor as a charge sensor. This system can be used as a platform to examine the interactions of single molecules with carbon nanotubes and has many potential applications for the study of molecular recognition and other biological processes occurring at cell membranes.
AB - Carbon nanotube transistors combine molecular-scale dimensions with excellent electronic properties, offering unique opportunities for chemical and biological sensing. Here, we form supported lipid bilayers over single-walled carbon nanotube transistors. We first study the physical properties of the nanotube/supported lipid bilayer structure using fluorescence techniques. Whereas lipid molecules can diffuse freely across the nanotube, a membrane-bound protein (tetanus toxin) sees the nanotube as a barrier. Moreover, the size of the barrier depends on the diameter of the nanotube-with larger nanotubes presenting bigger obstacles to diffusion. We then demonstrate detection of protein binding (streptavidin) to the supported lipid bilayer using the nanotube transistor as a charge sensor. This system can be used as a platform to examine the interactions of single molecules with carbon nanotubes and has many potential applications for the study of molecular recognition and other biological processes occurring at cell membranes.
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U2 - 10.1038/nnano.2007.34
DO - 10.1038/nnano.2007.34
M3 - Article
C2 - 18654251
AN - SCOPUS:33847627519
SN - 1748-3387
VL - 2
SP - 185
EP - 190
JO - Nature Nanotechnology
JF - Nature Nanotechnology
IS - 3
ER -