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Keyphrases
Co-treatment
100%
Human Pancreatic Cancer
100%
Panobinostat
100%
Histone Deacetylase Inhibitor (HDACi)
100%
PI3K-mTOR Inhibitors
100%
NVP-BEZ235
100%
BEZ235
88%
Pancreatic Duct Cells
44%
AKT1
33%
Nude Mice
22%
Tumor Growth
22%
Pancreatic Ductal Adenocarcinoma
22%
TORC1
22%
Human Pancreatic Ductal Adenocarcinoma
22%
Attenuation
11%
Cell Viability
11%
Cell-Associated
11%
Induced Apoptosis
11%
Induced Loss
11%
Xenograft
11%
Mammalian Target of Rapamycin (mTOR)
11%
P70S6K
11%
MTOR Inhibitor
11%
4E-BP1
11%
Genetic Modification
11%
Combined Treatment
11%
Bcl-xL
11%
ERK2
11%
PI3K Signaling
11%
Anti-apoptotic Proteins
11%
TORC2
11%
In Vivo Applications
11%
Inhibitory Proteins
11%
P27Kip1
11%
P21Cip1
11%
PI3K Inhibitor
11%
Cell Cycle Progression
11%
KRAS mutation
11%
In Vivo Evaluation
11%
PI3K-AKT-mTOR Pathway
11%
K-ras
11%
PANC-1
11%
AKT2
11%
Superior Activity
11%
Heterotransplant
11%
Superior Support
11%
Medicine and Dentistry
Pancreas Cancer
100%
Mammalian Target of Rapamycin Inhibitor
100%
BEZ235
100%
Histone Deacetylase Inhibitor
100%
Panobinostat
90%
Pancreas Adenocarcinoma
70%
Protein Kinase B
40%
Tumor Progression
20%
Xenograft
20%
Cell Viability
10%
Cell Cycle
10%
Phosphotransferase
10%
Programmed Cell Death
10%
Mitogen Activated Protein Kinase 3
10%
Bcl-xL
10%
Mechanistic Target of Rapamycin
10%
BIM Protein
10%
Cyclin Dependent Kinase Inhibitor 1
10%
Gene Mutation
10%
PI3K/AKT/mTOR Pathway
10%
Cell Cycle Progression
10%
CDKN1B
10%
Protein Kinase B Beta
10%
Pharmacology, Toxicology and Pharmaceutical Science
Pancreas Cancer
100%
Dactolisib
100%
Mammalian Target of Rapamycin Inhibitor
100%
Histone Deacetylase Inhibitor
100%
Panobinostat
90%
Pancreas Adenocarcinoma
70%
Protein Kinase B
50%
Nude Mouse
20%
Tumor Growth
20%
Mitogen Activated Protein Kinase 3
10%
Phosphotransferase
10%
Cell Viability
10%
Cyclin Dependent Kinase Inhibitor 1
10%
Mammalian Target of Rapamycin
10%
BIM Protein
10%
Cyclin Dependent Kinase Inhibitor 1B
10%
Protein Kinase B Beta
10%