Superficial CD34-positive fibroblastic tumor (SCPFT): A review of pathological and clinical features

Haneen T. Salah, Julieta A. D'ardis, Donghwa Baek, Mary R. Schwartz, Alberto G. Ayala, Jae Y. Ro

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Superficial CD34-positive fibroblastic tumor (SCPFT) is a recently described rare mesenchymal tumor of borderline malignancy. It generally involves superficial soft tissue, with a predilection to the lower extremities. Microscopically this tumor is characterized by a fascicular and storiform growth pattern, spindled to epithelioid cells, nuclear atypia with pleomorphism, and eosinophilic granular, and fibrillar to glassy cytoplasm. Strong diffuse immunoreactivity for CD34 is very characteristic of this entity. Due to under-recognition, this tumor is generally underreported. Additionally, cases of recurrence are rarely reported in the literature. We will comprehensively review the English language literature on all reported cases of SCPFT, with emphasis on recurrence.

Original languageEnglish (US)
Article number151937
Pages (from-to)151937
JournalAnnals of Diagnostic Pathology
StatePublished - Jun 2022


  • CD34-positive
  • Fibroblastic tumors
  • Local recurrence
  • Superficial location
  • Antigens, CD34
  • Neoplasms, Connective and Soft Tissue
  • Neoplasms, Fibrous Tissue/pathology
  • Epithelioid Cells/pathology
  • Soft Tissue Neoplasms/diagnosis
  • Humans
  • Biomarkers, Tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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