[11C]befloxatone distribution is well correlated to monoamine oxidase A protein levels in the human brain

Paolo Zanotti-Fregonara, Michel Bottlaender

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

[11C]befloxatone is a positron emission tomography radioligand to image monoamine oxidase A (MAO-A) in the brain, which has been used in preclinical studies and in clinical protocols. However, a recent study found that [11C]befloxatone binding potential (k 3 /k 4) has a poor correlation with MAO-A protein levels measured in the human brain. We here show that this poor correlation only depends on the choice of the parameter when performing kinetic modeling. In particular, the total volume of distribution of [11C]befloxatone shows a tight correlation with both protein and mRNA levels of MAO-A in the human brain.

Original languageEnglish (US)
Pages (from-to)1951-1952
Number of pages2
JournalJournal of Cerebral Blood Flow and Metabolism
Volume34
Issue number12
DOIs
StatePublished - Dec 11 2014

Keywords

  • PET
  • [11C]befloxatone
  • brain imaging
  • monoamine oxidase A

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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