¹¹C-ER176, a radioligand for 18-kDa translocator protein, has adequate sensitivity to robustly image all three affinity genotypes in human brain

Keyphrases

• Genotype 100%
• Human Brain 100%
• Radioligand 100%
• Translocator Protein 18 kDa 100%
• Affinity Binder 100%
• High Affinity 50%
• Low Affinity 33%
• Rs6971 33%
• Translocator Protein 25%
• After Injection 16%
• Healthy Volunteers 16%
• Methyl 16%
• PK11195 16%
• PET Imaging 16%
• Chlorophenyl 16%
• Carboxamide 16%
• Neuroinflammation 8%
• Whole-body 8%
• Lung 8%
• Spleen 8%
• Non-specific Binding 8%
• In Vitro Study 8%
• Benzyl 8%
• Single nucleotide Polymorphism 8%
• Peripheral Organs 8%
• Ethyl 8%
• Low Sensitivity 8%
• Specific Binding 8%
• N-acetylation 8%
• Occupancy 8%
• Butyl 8%
• Low Signal-to-noise Ratio 8%
• Binding Potential 8%
• Acetamide 8%
• Volume of Distribution 8%
• Brain Scans 8%
• Monkey Brain 8%
• In Vivo Properties 8%
• Protein Density 8%
• Brain PET Imaging 8%
• PBR28 8%
• Pyridinamine 8%
• Phenoxy 8%
• Occupancy Plot 8%
• XBD173 8%
• New Analogs 8%

Neuroscience

• Radioligand 100%
• Translocator Protein 100%
• Human Brain 100%
• In Vitro 80%
• positron emission tomographic scan 60%
• In Vivo 40%
• Carboxamide 40%
• Signal-to-Noise Ratio 20%
• Single-Nucleotide Polymorphism 20%
• Acetamide 20%
• Emapunil 20%