TY - JOUR
T1 - SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC-1α
AU - Cai, Rong
AU - Yu, Tingting
AU - Huang, Chao
AU - Xia, Xuefeng
AU - Liu, Xiaobing
AU - Gu, Jianmin
AU - Xue, Song
AU - Yeh, Edward T H
AU - Cheng, Jinke
PY - 2012/12/28
Y1 - 2012/12/28
N2 - Peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1α (PGC-1α) is a master regulator of mitochondrial biogenesis in response to changes in the cellular environment, physiological or pathological status of mammals. PGC-1α is known to be modified by SUMO (Small Ubiquitin-like Modifier). However, it is not known whether SUMOylation could affect the function of PGC-1α in mitochondrial biogenesis and that how PGC-1α SUMOylation is regulated. In this study, we have identified the role of Sentrin/SUMO-specific protease 1 (SENP1) as a specific SUMO protease to regulate SUMOylation status of PGC-1α. More importantly, we have also found that SENP1 promotes PGC-1α transcription activity, which is essential for the expression of mitochondrial genes and subsequently mitochondrial biogenesis. Thus, we reveal that the SUMOylation of PGC-1α controlled by SENP1 plays an important role in mitochondrial biogenesis and function.
AB - Peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1α (PGC-1α) is a master regulator of mitochondrial biogenesis in response to changes in the cellular environment, physiological or pathological status of mammals. PGC-1α is known to be modified by SUMO (Small Ubiquitin-like Modifier). However, it is not known whether SUMOylation could affect the function of PGC-1α in mitochondrial biogenesis and that how PGC-1α SUMOylation is regulated. In this study, we have identified the role of Sentrin/SUMO-specific protease 1 (SENP1) as a specific SUMO protease to regulate SUMOylation status of PGC-1α. More importantly, we have also found that SENP1 promotes PGC-1α transcription activity, which is essential for the expression of mitochondrial genes and subsequently mitochondrial biogenesis. Thus, we reveal that the SUMOylation of PGC-1α controlled by SENP1 plays an important role in mitochondrial biogenesis and function.
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U2 - 10.1074/jbc.M112.422626
DO - 10.1074/jbc.M112.422626
M3 - Article
C2 - 23152500
AN - SCOPUS:84871821904
SN - 0021-9258
VL - 287
SP - 44464
EP - 44470
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 53
ER -