Sugar-decorated hydroxyapatite: An inorganic material bioactivated with carbohydrates

Laura Russo, Elena Landi, Anna Tampieri, Antonino Natalello, Silvia M. Doglia, Luca Gabrielli, Laura Cipolla, Francesco Nicotra

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

An efficient method for the direct and covalent decoration of granules of nanostructured apatite with a sample monosaccharide is presented; the hydroxyapatite material was directly functionalised with a short azido-containing spacer arm, to which α-propargyl glucopyranoside has been chemoselectively ligated by Huisgen-type cycloaddition. The 'glycosylated' hydroxypatite was characterised by its ability to interact with glucose recognising lectins.

Original languageEnglish (US)
Pages (from-to)1564-1568
Number of pages5
JournalCarbohydrate Research
Volume346
Issue number12
DOIs
StatePublished - Sep 6 2011

Keywords

  • Biomaterials
  • Click chemistry
  • Hydroxyapatite
  • Lectin
  • Propargyl glycosides

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry
  • Organic Chemistry

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