Sugar-decorated hydroxyapatite: An inorganic material bioactivated with carbohydrates

Laura Russo; Elena Landi; Anna Tampieri; Antonino Natalello; Silvia M. Doglia; Luca Gabrielli; Laura Cipolla; Francesco Nicotra

doi:10.1016/j.carres.2011.04.044

Sugar-decorated hydroxyapatite: An inorganic material bioactivated with carbohydrates

Laura Russo, Elena Landi, Anna Tampieri, Antonino Natalello, Silvia M. Doglia, Luca Gabrielli, Laura Cipolla, Francesco Nicotra

Houston Methodist

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

An efficient method for the direct and covalent decoration of granules of nanostructured apatite with a sample monosaccharide is presented; the hydroxyapatite material was directly functionalised with a short azido-containing spacer arm, to which α-propargyl glucopyranoside has been chemoselectively ligated by Huisgen-type cycloaddition. The 'glycosylated' hydroxypatite was characterised by its ability to interact with glucose recognising lectins.

Original language	English (US)
Pages (from-to)	1564-1568
Number of pages	5
Journal	Carbohydrate Research
Volume	346
Issue number	12
DOIs	https://doi.org/10.1016/j.carres.2011.04.044
State	Published - Sep 6 2011

Keywords

Biomaterials
Click chemistry
Hydroxyapatite
Lectin
Propargyl glycosides

ASJC Scopus subject areas

Biochemistry
Analytical Chemistry
Organic Chemistry

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10.1016/j.carres.2011.04.044

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title = "Sugar-decorated hydroxyapatite: An inorganic material bioactivated with carbohydrates",

abstract = "An efficient method for the direct and covalent decoration of granules of nanostructured apatite with a sample monosaccharide is presented; the hydroxyapatite material was directly functionalised with a short azido-containing spacer arm, to which α-propargyl glucopyranoside has been chemoselectively ligated by Huisgen-type cycloaddition. The 'glycosylated' hydroxypatite was characterised by its ability to interact with glucose recognising lectins.",

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T2 - An inorganic material bioactivated with carbohydrates

AU - Russo, Laura

AU - Landi, Elena

AU - Tampieri, Anna

AU - Natalello, Antonino

AU - Doglia, Silvia M.

AU - Gabrielli, Luca

AU - Cipolla, Laura

AU - Nicotra, Francesco

PY - 2011/9/6

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N2 - An efficient method for the direct and covalent decoration of granules of nanostructured apatite with a sample monosaccharide is presented; the hydroxyapatite material was directly functionalised with a short azido-containing spacer arm, to which α-propargyl glucopyranoside has been chemoselectively ligated by Huisgen-type cycloaddition. The 'glycosylated' hydroxypatite was characterised by its ability to interact with glucose recognising lectins.

AB - An efficient method for the direct and covalent decoration of granules of nanostructured apatite with a sample monosaccharide is presented; the hydroxyapatite material was directly functionalised with a short azido-containing spacer arm, to which α-propargyl glucopyranoside has been chemoselectively ligated by Huisgen-type cycloaddition. The 'glycosylated' hydroxypatite was characterised by its ability to interact with glucose recognising lectins.

KW - Biomaterials

KW - Click chemistry

KW - Hydroxyapatite

KW - Lectin

KW - Propargyl glycosides

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Sugar-decorated hydroxyapatite: An inorganic material bioactivated with carbohydrates

Abstract

Keywords

ASJC Scopus subject areas

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