Successful treatment of juvenile xanthogranuloma using bevacizumab

Noy Ashkenazy; Christopher R. Henry; Ashkan M. Abbey; Craig A. McKeown; Audina M. Berrocal; Timothy G. Murray

doi:10.1016/j.jaapos.2014.01.007

Successful treatment of juvenile xanthogranuloma using bevacizumab

Noy Ashkenazy, Christopher R. Henry, Ashkan M. Abbey, Craig A. McKeown, Audina M. Berrocal, Timothy G. Murray

Houston Methodist

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Juvenile xanthogranuloma (JXG) is an uncommon non-Langerhans cell histiocytic disorder that occurs predominantly in infants. Traditional treatment of ocular JXG involves the administration of topical or local corticosteroids. We treated 2 children with JXG refractory to local corticosteroid therapy with off-label intraocular bevacizumab. To our knowledge, this is the first report of successful use of bevacizumab for ocular JXG.

Original language	English (US)
Pages (from-to)	295-297
Number of pages	3
Journal	Journal of AAPOS
Volume	18
Issue number	3
DOIs	https://doi.org/10.1016/j.jaapos.2014.01.007
State	Published - Jun 2014

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Ophthalmology

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10.1016/j.jaapos.2014.01.007

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title = "Successful treatment of juvenile xanthogranuloma using bevacizumab",

abstract = "Juvenile xanthogranuloma (JXG) is an uncommon non-Langerhans cell histiocytic disorder that occurs predominantly in infants. Traditional treatment of ocular JXG involves the administration of topical or local corticosteroids. We treated 2 children with JXG refractory to local corticosteroid therapy with off-label intraocular bevacizumab. To our knowledge, this is the first report of successful use of bevacizumab for ocular JXG.",

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AU - Henry, Christopher R.

AU - Abbey, Ashkan M.

AU - McKeown, Craig A.

AU - Berrocal, Audina M.

AU - Murray, Timothy G.

PY - 2014/6

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N2 - Juvenile xanthogranuloma (JXG) is an uncommon non-Langerhans cell histiocytic disorder that occurs predominantly in infants. Traditional treatment of ocular JXG involves the administration of topical or local corticosteroids. We treated 2 children with JXG refractory to local corticosteroid therapy with off-label intraocular bevacizumab. To our knowledge, this is the first report of successful use of bevacizumab for ocular JXG.

AB - Juvenile xanthogranuloma (JXG) is an uncommon non-Langerhans cell histiocytic disorder that occurs predominantly in infants. Traditional treatment of ocular JXG involves the administration of topical or local corticosteroids. We treated 2 children with JXG refractory to local corticosteroid therapy with off-label intraocular bevacizumab. To our knowledge, this is the first report of successful use of bevacizumab for ocular JXG.

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Successful treatment of juvenile xanthogranuloma using bevacizumab

Abstract

ASJC Scopus subject areas

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