Successful treatment of bloodstream infection due to metallo-β-lactamase-producing Stenotrophomonas maltophilia in a renal transplant patient

Maria F. Mojica; Christopher P. Ouellette; Amy Leber; M. Brian Becknell; Monica I. Ardura; Federico Perez; Masako Shimamura; Robert A. Bonomo; Samuel L. Aitken; Samuel A. Shelburne

doi:10.1128/AAC.00264-16

Successful treatment of bloodstream infection due to metallo-β-lactamase-producing Stenotrophomonas maltophilia in a renal transplant patient

Maria F. Mojica, Christopher P. Ouellette, Amy Leber, M. Brian Becknell, Monica I. Ardura, Federico Perez, Masako Shimamura, Robert A. Bonomo, Samuel L. Aitken, Samuel A. Shelburne

Houston Methodist

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

Stenotrophomonas maltophilia is an emerging multidrug-resistant (MDR) opportunistic pathogen for which new antibiotic options are urgently needed. We report our clinical experience treating a 19-year-old renal transplant recipient who developed prolonged bacteremia due to metallo-β-lactamase-producing S. maltophilia refractory to conventional treatment. The infection recurred despite a prolonged course of colistimethate sodium (colistin) but resolved with the use of a novel drug combination with clinical efficacy against the patient's S. maltophilia isolate.

Original language	English (US)
Pages (from-to)	5130-5134
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	60
Issue number	9
DOIs	https://doi.org/10.1128/AAC.00264-16
State	Published - Sep 1 2016

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Mojica, M. F., Ouellette, C. P., Leber, A., Becknell, M. B., Ardura, M. I., Perez, F., Shimamura, M., Bonomo, R. A., Aitken, S. L., & Shelburne, S. A. (2016). Successful treatment of bloodstream infection due to metallo-β-lactamase-producing Stenotrophomonas maltophilia in a renal transplant patient. Antimicrobial Agents and Chemotherapy, 60(9), 5130-5134. https://doi.org/10.1128/AAC.00264-16

Mojica, MF, Ouellette, CP, Leber, A, Becknell, MB, Ardura, MI, Perez, F, Shimamura, M, Bonomo, RA, Aitken, SL & Shelburne, SA 2016, 'Successful treatment of bloodstream infection due to metallo-β-lactamase-producing Stenotrophomonas maltophilia in a renal transplant patient', Antimicrobial Agents and Chemotherapy, vol. 60, no. 9, pp. 5130-5134. https://doi.org/10.1128/AAC.00264-16

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abstract = "Stenotrophomonas maltophilia is an emerging multidrug-resistant (MDR) opportunistic pathogen for which new antibiotic options are urgently needed. We report our clinical experience treating a 19-year-old renal transplant recipient who developed prolonged bacteremia due to metallo-β-lactamase-producing S. maltophilia refractory to conventional treatment. The infection recurred despite a prolonged course of colistimethate sodium (colistin) but resolved with the use of a novel drug combination with clinical efficacy against the patient's S. maltophilia isolate.",

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AU - Becknell, M. Brian

AU - Ardura, Monica I.

AU - Perez, Federico

AU - Shimamura, Masako

AU - Bonomo, Robert A.

AU - Aitken, Samuel L.

AU - Shelburne, Samuel A.

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AB - Stenotrophomonas maltophilia is an emerging multidrug-resistant (MDR) opportunistic pathogen for which new antibiotic options are urgently needed. We report our clinical experience treating a 19-year-old renal transplant recipient who developed prolonged bacteremia due to metallo-β-lactamase-producing S. maltophilia refractory to conventional treatment. The infection recurred despite a prolonged course of colistimethate sodium (colistin) but resolved with the use of a novel drug combination with clinical efficacy against the patient's S. maltophilia isolate.

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Successful treatment of bloodstream infection due to metallo-β-lactamase-producing Stenotrophomonas maltophilia in a renal transplant patient

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