Successful treatment of bloodstream infection due to metallo-β-lactamase-producing Stenotrophomonas maltophilia in a renal transplant patient

Maria F. Mojica, Christopher P. Ouellette, Amy Leber, M. Brian Becknell, Monica I. Ardura, Federico Perez, Masako Shimamura, Robert A. Bonomo, Samuel L. Aitken, Samuel A. Shelburne

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Stenotrophomonas maltophilia is an emerging multidrug-resistant (MDR) opportunistic pathogen for which new antibiotic options are urgently needed. We report our clinical experience treating a 19-year-old renal transplant recipient who developed prolonged bacteremia due to metallo-β-lactamase-producing S. maltophilia refractory to conventional treatment. The infection recurred despite a prolonged course of colistimethate sodium (colistin) but resolved with the use of a novel drug combination with clinical efficacy against the patient's S. maltophilia isolate.

Original languageEnglish (US)
Pages (from-to)5130-5134
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume60
Issue number9
DOIs
StatePublished - Sep 1 2016

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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