@article{1b1f54f1c32d43c98db459af00af14fa,
title = "Successful aging: Advancing the science of physical independence in older adults",
abstract = "The concept of 'successful aging' has long intrigued the scientific community. Despite this long-standing interest, a consensus definition has proven to be a difficult task, due to the inherent challenge involved in defining such a complex, multi-dimensional phenomenon. The lack of a clear set of defining characteristics for the construct of successful aging has made comparison of findings across studies difficult and has limited advances in aging research. A consensus on markers of successful aging is furthest developed is the domain of physical functioning. For example, walking speed appears to be an excellent surrogate marker of overall health and predicts the maintenance of physical independence, a cornerstone of successful aging. The purpose of the present article is to provide an overview and discussion of specific health conditions, behavioral factors, and biological mechanisms that mark declining mobility and physical function and promising interventions to counter these effects. With life expectancy continuing to increase in the United States and developed countries throughout the world, there is an increasing public health focus on the maintenance of physical independence among all older adults.",
keywords = "Age, Healthspan, Longevity, Mobility, Obesity, Sarcopenia",
author = "Anton, {Stephen D.} and Woods, {Adam J.} and Tetso Ashizawa and Diana Barb and Buford, {Thomas W.} and Carter, {Christy S.} and Clark, {David J.} and Cohen, {Ronald A.} and Corbett, {Duane B.} and Yenisel Cruz-Almeida and Vonetta Dotson and Natalie Ebner and Efron, {Philip A.} and Fillingim, {Roger B.} and Foster, {Thomas C.} and Gundermann, {David M.} and Joseph, {Anna Maria} and Christy Karabetian and Christiaan Leeuwenburgh and Manini, {Todd M.} and Michael Marsiske and Mankowski, {Robert T.} and Mutchie, {Heather L.} and Perri, {Michael G.} and Sanjay Ranka and Parisa Rashidi and Bhanuprasad Sandesara and Scarpace, {Philip J.} and Sibille, {Kimberly T.} and Solberg, {Laurence M.} and Shinichi Someya and Connie Uphold and Stephanie Wohlgemuth and Wu, {Samuel Shangwu} and Marco Pahor",
note = "Funding Information: Support was provided by the University of Florida{\textquoteright}s Claude D. Pepper Older Americans Independence Center (NIH/NIA P30AG028740), and Clinical and Translational Science Institute (NIH/NCRR UL1TR000064). Stephen Anton was previously supported by the Thomas H. Maren Foundation. Funding Information: Support was provided by the University of Florida{\textquoteright}s Claude D. Pepper Older Americans Independence Center ( NIH/NIA P30AG028740 ), and Clinical and Translational Science Institute ( NIH/NCRR UL1TR000064 ). Stephen Anton was previously supported by the Thomas H. Maren Foundation. Publisher Copyright: {\textcopyright} 2015 Elsevier B.V. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",
year = "2015",
month = nov,
day = "1",
doi = "10.1016/j.arr.2015.09.005",
language = "English (US)",
volume = "24",
pages = "304--327",
journal = "Ageing Research Reviews",
issn = "1568-1637",
publisher = "Elsevier Ireland Ltd",
}