Subcutaneous nodular amyloidosis: A case report and review of the literature

Tracy U. Nguyen, John S. Oghalai, David K. McGregor, Namieta M. Janssen, David P. Huston

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Amyloidosis typically manifests with disseminated infiltration of multiple organ systems. Rarely, amyloidosis may be localized. We report a patient with localized subcutaneous nodular amyloidosis, without systemic amyloid involvement or myeloma, whose presenting symptom was multiple discrete neck nodules. Immunohistochemical analysis showed the amyloid deposits to be derived from lambda light chains. Twenty-four month follow-up showed minimal disease progression. A literature review showed only 5 reported cases of subcutaneous nodular amyloidosis. This is the first description of a patient with subcutaneous nodular amyloidosis derived from lambda light chains.

Original languageEnglish (US)
Pages (from-to)346-348
Number of pages3
JournalHuman Pathology
Issue number3
StatePublished - 2001


  • Amyloidosis
  • Nodular amyloidosis
  • Primary amyloidosis
  • Subcutaneous nodular amyloidosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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