Subacute exposure to low concentrations of toluene affects dopamine-mediated locomotor activity in the rat

G. von Euler, S. O. Ögren, S. C. Bondy, M. McKee, M. Warner, J. Å Gustafsson, P. Eneroth, K. Fuxe

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

The effects of low concentrations of toluene (40-80 ppm, 3 days, 6 h/day) were investigated on spontaneous and on apomorphine-induced locomotor activity in the rat, and were correlated to effects on S(-)[N-propyl-3H(N)]-propylnorapomorphine ([3H]NPA) binding in rat neostriatal membranes, on membrane fluidity, membrane leakage, and calcium levels in synaptosomes from the frontoparietal cortex, the neostriatum and the subcortical limbic area, and on serum hormone levels. Toluene exposure (80 ppm, post-exposure delay 18 h) alone did not affect locomotor activity, but attenuated apomorphine-induced (0.05 mg/kg, s.c.) suppression of rearing, and potentiated apomorphine-induced (1 mg/kg, s.c.) increases in locomotion and rearing. Toluene exposure increased the KD value of [3H]NPA binding without affecting the Bmax. All these effects were absent at 40 ppm of toluene or at a post-exposure delay of 42 h. Toluene exposure (80 ppm, post-exposure delay of 18 h) did not affect the serum levels of prolactin, TSH, corticosterone, or aldosterone, or synaptosomal membrane fluidity and calcium levels, whereas membrane leakage was increased in the neostriatum. The present study indicates that the reduction of D-2 receptor affinity by short-term, low-dose toluene exposure is accompanied by a reduced D-2 autoreceptor function and an enhanced postsynaptic D-2 receptor function.

Original languageEnglish (US)
Pages (from-to)333-349
Number of pages17
JournalToxicology
Volume67
Issue number3
DOIs
StatePublished - Mar 1991

Keywords

  • Apomorphine
  • Basal ganglia
  • Calcium
  • Dopamine receptor
  • Membrane fluidity
  • Prolactin

ASJC Scopus subject areas

  • Toxicology

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