Study of rare earth encapsulated carbon nanomolecules for biomedical uses

Li Qu; Wenbin Cao; Gengmei Xing; Jun Zhang; Hui Yuan; Jun Tang; Yue Cheng; Bo Zhang; Yuliang Zhao; Hao Lei

doi:10.1016/j.jallcom.2004.12.101

Study of rare earth encapsulated carbon nanomolecules for biomedical uses

Li Qu, Wenbin Cao, Gengmei Xing, Jun Zhang, Hui Yuan, Jun Tang, Yue Cheng, Bo Zhang, Yuliang Zhao, Hao Lei

Houston Methodist

Research output: Contribution to journal › Conference article › peer-review

37 Scopus citations

Abstract

Gd@C₈₂(OH)₄₀ has been proposed to be as a new generation of the magnetic resonance imaging (MRI) contrast agent, but water-soluble fullerenols Gd@C₈₂(OH)_n with n > 36 can easily lead to open-caged structures of a high instability. This restricts the practical bio-uses of Gd-metallofullerenols with a large number of hydroxyl groups. To explore how the imaging efficiency varies with decreasing hydroxyl number in Gd@C₈₂(OH)_n of a good stability in vivo, Gd@C₈₂(OH)₂₂ was prepared, characterized and its imaging efficiency in mice was studied. This work aims at searching a chemical form of water-soluble Gd-metallofullerenols that satisfy both requirements of the good stability and high imaging efficiency in vivo. The results indicate that the proton relaxivity of Gd@C₈₂(OH)₂₂ is lower than that of Gd@C₈₂(OH)₄₀, but still higher than the commercial Gd-DTPA MRI contrast agent.

Original language	English (US)
Pages (from-to)	400-404
Number of pages	5
Journal	Journal of Alloys and Compounds
Volume	408-412
DOIs	https://doi.org/10.1016/j.jallcom.2004.12.101
State	Published - Feb 9 2006
Event	Proceedings of the Rare Earths'04 in Nara, Japan - Duration: Nov 7 2004 → Nov 12 2004

Keywords

Gd-metallofullerenol
Gd@C(OH)
In vivo
MRI contrast agent
Stability

ASJC Scopus subject areas

Metals and Alloys

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10.1016/j.jallcom.2004.12.101

Cite this

@article{536482ae308a4852bcdd332cf23b0c9f,

title = "Study of rare earth encapsulated carbon nanomolecules for biomedical uses",

abstract = "Gd@C82(OH)40 has been proposed to be as a new generation of the magnetic resonance imaging (MRI) contrast agent, but water-soluble fullerenols Gd@C82(OH)n with n > 36 can easily lead to open-caged structures of a high instability. This restricts the practical bio-uses of Gd-metallofullerenols with a large number of hydroxyl groups. To explore how the imaging efficiency varies with decreasing hydroxyl number in Gd@C82(OH)n of a good stability in vivo, Gd@C82(OH)22 was prepared, characterized and its imaging efficiency in mice was studied. This work aims at searching a chemical form of water-soluble Gd-metallofullerenols that satisfy both requirements of the good stability and high imaging efficiency in vivo. The results indicate that the proton relaxivity of Gd@C82(OH)22 is lower than that of Gd@C82(OH)40, but still higher than the commercial Gd-DTPA MRI contrast agent.",

keywords = "Gd-metallofullerenol, Gd@C(OH), In vivo, MRI contrast agent, Stability",

author = "Li Qu and Wenbin Cao and Gengmei Xing and Jun Zhang and Hui Yuan and Jun Tang and Yue Cheng and Bo Zhang and Yuliang Zhao and Hao Lei",

note = "Funding Information: We thank Prof. Yuanfang Liu of Peking University for discussion. Authors acknowledge the fund supports from Ministry of Science \& Technology (2001CCA03800), National Natural Science Foundation of China (10490180), Chinese Academy of Sciences, National Centre for Nanoscience and Nanotechnology China (90406024), and State Key Laboratory of spectroscopy and Atomic and Molecular Physics (T152302).; Proceedings of the Rare Earths'04 in Nara, Japan ; Conference date: 07-11-2004 Through 12-11-2004",

year = "2006",

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day = "9",

doi = "10.1016/j.jallcom.2004.12.101",

language = "English (US)",

volume = "408-412",

pages = "400--404",

journal = "Journal of Alloys and Compounds",

issn = "0925-8388",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Study of rare earth encapsulated carbon nanomolecules for biomedical uses

AU - Qu, Li

AU - Cao, Wenbin

AU - Xing, Gengmei

AU - Zhang, Jun

AU - Yuan, Hui

AU - Tang, Jun

AU - Cheng, Yue

AU - Zhang, Bo

AU - Zhao, Yuliang

AU - Lei, Hao

N1 - Funding Information: We thank Prof. Yuanfang Liu of Peking University for discussion. Authors acknowledge the fund supports from Ministry of Science & Technology (2001CCA03800), National Natural Science Foundation of China (10490180), Chinese Academy of Sciences, National Centre for Nanoscience and Nanotechnology China (90406024), and State Key Laboratory of spectroscopy and Atomic and Molecular Physics (T152302).

PY - 2006/2/9

Y1 - 2006/2/9

N2 - Gd@C82(OH)40 has been proposed to be as a new generation of the magnetic resonance imaging (MRI) contrast agent, but water-soluble fullerenols Gd@C82(OH)n with n > 36 can easily lead to open-caged structures of a high instability. This restricts the practical bio-uses of Gd-metallofullerenols with a large number of hydroxyl groups. To explore how the imaging efficiency varies with decreasing hydroxyl number in Gd@C82(OH)n of a good stability in vivo, Gd@C82(OH)22 was prepared, characterized and its imaging efficiency in mice was studied. This work aims at searching a chemical form of water-soluble Gd-metallofullerenols that satisfy both requirements of the good stability and high imaging efficiency in vivo. The results indicate that the proton relaxivity of Gd@C82(OH)22 is lower than that of Gd@C82(OH)40, but still higher than the commercial Gd-DTPA MRI contrast agent.

AB - Gd@C82(OH)40 has been proposed to be as a new generation of the magnetic resonance imaging (MRI) contrast agent, but water-soluble fullerenols Gd@C82(OH)n with n > 36 can easily lead to open-caged structures of a high instability. This restricts the practical bio-uses of Gd-metallofullerenols with a large number of hydroxyl groups. To explore how the imaging efficiency varies with decreasing hydroxyl number in Gd@C82(OH)n of a good stability in vivo, Gd@C82(OH)22 was prepared, characterized and its imaging efficiency in mice was studied. This work aims at searching a chemical form of water-soluble Gd-metallofullerenols that satisfy both requirements of the good stability and high imaging efficiency in vivo. The results indicate that the proton relaxivity of Gd@C82(OH)22 is lower than that of Gd@C82(OH)40, but still higher than the commercial Gd-DTPA MRI contrast agent.

KW - Gd-metallofullerenol

KW - Gd@C(OH)

KW - In vivo

KW - MRI contrast agent

KW - Stability

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JO - Journal of Alloys and Compounds

JF - Journal of Alloys and Compounds

T2 - Proceedings of the Rare Earths'04 in Nara, Japan

Y2 - 7 November 2004 through 12 November 2004

ER -

Study of rare earth encapsulated carbon nanomolecules for biomedical uses

Abstract

Keywords

ASJC Scopus subject areas

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