Study of rare earth encapsulated carbon nanomolecules for biomedical uses

Li Qu, Wenbin Cao, Gengmei Xing, Jun Zhang, Hui Yuan, Jun Tang, Yue Cheng, Bo Zhang, Yuliang Zhao, Hao Lei

Research output: Contribution to journalConference article

34 Scopus citations

Abstract

Gd@C82(OH)40 has been proposed to be as a new generation of the magnetic resonance imaging (MRI) contrast agent, but water-soluble fullerenols Gd@C82(OH)n with n > 36 can easily lead to open-caged structures of a high instability. This restricts the practical bio-uses of Gd-metallofullerenols with a large number of hydroxyl groups. To explore how the imaging efficiency varies with decreasing hydroxyl number in Gd@C82(OH)n of a good stability in vivo, Gd@C82(OH)22 was prepared, characterized and its imaging efficiency in mice was studied. This work aims at searching a chemical form of water-soluble Gd-metallofullerenols that satisfy both requirements of the good stability and high imaging efficiency in vivo. The results indicate that the proton relaxivity of Gd@C82(OH)22 is lower than that of Gd@C82(OH)40, but still higher than the commercial Gd-DTPA MRI contrast agent.

Original languageEnglish (US)
Pages (from-to)400-404
Number of pages5
JournalJournal of Alloys and Compounds
Volume408-412
DOIs
StatePublished - Feb 9 2006
EventProceedings of the Rare Earths'04 in Nara, Japan -
Duration: Nov 7 2004Nov 12 2004

Keywords

  • Gd-metallofullerenol
  • Gd@C(OH)
  • In vivo
  • MRI contrast agent
  • Stability

ASJC Scopus subject areas

  • Metals and Alloys

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