Study of extracellular matrix in vocal fold biomechanics using a two-phase model

Amir K. Miri, Nicole Y.K. Li, Reza Avazmohammadi, Susan L. Thibeault, Rosaire Mongrain, Luc Mongeau

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The extracellular matrix (ECM) of the vocal fold tissue consists primarily of fibrous and interstitial proteins. The purpose of this study was to investigate the effects of selective enzymatic digestion of two ECM proteins, namely elastin and versican, on the elasticity of rabbit vocal fold tissue. Quasi-static, sinusoidal, uniaxial tensile tests were performed. The data were analyzed within the framework of a model of the ECM as a two-phase composite material consisting of collagen fibrils as the reinforcing fibers and noncollagenous ECM proteins as the matrix. To validate the two-phase model, the regression parameters for the fibers’ volume fraction and shear modulus in a different animal model were compared with corresponding published data. The proposed model was then used to analyze rabbit vocal fold tissues. The mean value and the standard deviation of the fiber volume fraction were found to be 8.49 (Formula presented.) 3.75 % for the control samples ((Formula presented.)  = 4), 0.59 (Formula presented.) 1.13 % after elastin removal ((Formula presented.)  = 4), and 8.22 (Formula presented.) 1.06 % after versican removal ((Formula presented.)  = 4). The results suggest that elastin removal may lead to a reduction in tissue stiffness, through counteracting the reinforcement of collagen fibrils.

Original languageEnglish (US)
Pages (from-to)49-57
Number of pages9
JournalBiomechanics and Modeling in Mechanobiology
Volume14
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • Chondroitin
  • Elastin
  • Fiber-reinforced model
  • Hyperelasticity
  • Vocal folds

ASJC Scopus subject areas

  • Biotechnology
  • Modeling and Simulation
  • Mechanical Engineering

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