Study of electrolyte induced aggregation of gold nanoparticles capped by amino acids

Santosh Aryal, Remant Bahadur Remant, Narayan Bhattarai, Chul Ki Kim, Hak Yong Kim

Research output: Contribution to journalArticlepeer-review

92 Scopus citations


This work reports the electrolyte induced aggregation of gold nanoparticles directly conjugated to amino acid by chemical reduction in aqueous solution. The study was focused on three different classes of amino acids depending on the nature of α substituent, viz. l-cysteine, l-leucine, and l-asparagine. The band broadening and the red shift of surface plasmon band with increase in flocculation parameter showed the aggregation of gold nanoparticles with increase in electrolyte concentration and decrease in pH as monitored by UV-visible spectrophotometer. The 1H NMR spectrum demonstrates that the sulfide bond of cysteine and α amino group of leucine and asparagine interact with nanoparticles surface. Furthermore, transmission electron microscope (TEM) and thermogravimetric analysis (TGA) were performed to characterize and to support the fate of stabilization of the gold nanoparticles by amino acid.

Original languageEnglish (US)
Pages (from-to)191-197
Number of pages7
JournalJournal of Colloid And Interface Science
Issue number1
StatePublished - Jul 1 2006


  • Amino acid
  • Biomaterial
  • Gold
  • Nanoparticles
  • Surface modification

ASJC Scopus subject areas

  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
  • Surfaces and Interfaces


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